Developing Therapeutics for Serious Infectious Disease Targets Including
MRSA
PINE BROOK, N.J., Jan. 4 /PRNewswire/ -- Elusys Therapeutics, Inc., a
biotechnology company developing targeted anti-infective antibodies to
fight life-threatening infections, today announced that it has entered into
an exclusive collaborative research and license agreement with Pfizer Inc.
to develop new therapeutics for select infectious diseases using Elusys' HP
Antibody(TM) technology. The research collaboration will include ETI-211,
an HP Antibody for the treatment of methicillin-resistant Staphylococcus
aureus (MRSA) infections, in addition to research into other indications.
Under the terms of the agreement, Elusys and Pfizer will collaborate on
determining the full product profile of ETI-211 and perform research on
other indications of the HP Antibody technology. Elusys will receive an
upfront equity investment, research and development funding plus near-term
research milestones. Elusys has also granted Pfizer an option to acquire an
exclusive worldwide license to products developed under the agreement, and
upon exercise, the company will receive significant clinical and sales
milestones, as well as royalties on future sales of products resulting from
the collaboration.
HP Antibodies represent a unique approach to the treatment of a variety
of infectious diseases by enhancing the effectiveness of the body's natural
defense mechanisms to remove and destroy life-threatening pathogens. An HP
Antibody drug consists of a monoclonal antibody specific to an immune
receptor (CR1) that is chemically linked to a second antibody that binds a
particular pathogen. By targeting CR1, HP Antibodies enhance a natural
clearance mechanism and direct the rapid removal of pathogens into liver
macrophages, where they are destroyed and removed from the body.
Elizabeth Posillico, Ph.D., President & CEO of Elusys Therapeutics
commented, "We are delighted that Pfizer has recognized the potential value
of our HP Antibody technology as a novel approach for the treatment of
life- threatening infections. Pfizer's impressive scientific team and
expertise in infectious diseases provides Elusys with a strong partner to
advance HP Antibody products into human clinical trials." Dr. Posillico
added, "In parallel with the collaborative research on ETI-211, Elusys will
continue to advance its other internal clinical development programs. These
include Anthim(TM), our Phase I therapeutic for anthrax infection and our
HIV HP Antibody and CR1 Vaccine programs."
About ETI-211
ETI-211 is a proprietary HP Antibody drug being developed to treat MRSA
infections. In previously reported studies by Elusys, mice given ETI-211
prophylactically were completely protected against a lethal MRSA challenge.
Further, all ETI-211 treated animals survived a second lethal challenge of
either MRSA or S. epidermidis months later, with no additional drug
treatment.
About MRSA
MRSA is a type of bacteria that is resistant to almost all antibiotics.
MRSA accounts for over half of the infections in intensive care units in
the US alone, with an estimated 300,000 people contracting MRSA infections
each year, resulting in approximately 12,000 deaths. MRSA infections incur
significant treatment and hospitalization costs versus other infections,
exceeding $48,000 per patient on average.
About Elusys
Elusys Therapeutics is a privately-held biopharmaceutical company
focused on the development of targeted anti-infective therapeutics using
its proprietary HP Antibodies(TM) for the treatment of life-threatening
infectious diseases. Pfizer joins current venture investors including Essex
Woodlands Health Ventures LLC, Invesco Private Capital, Crescendo Ventures,
and MedImmune Ventures. For more information on Elusys, please visit
http://www.elusys.com.
SOURCE Elusys Therapeutics, Inc.
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Related links:
http://www.elusys.com
CONTACT:
Donna LaVoie, +1-978-745-4200, ext. 103, or
dlavoie@lavoiegroup.com; or Bryan Murphy, +1-978-745-4200, ext.
105, bmurphy@lavoiegroup.com; both of LaVoie Group for Elusys
Therapeutics, Inc.
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