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Ventana Medical Systems, Inc. Reports Record Revenues and Earnings for The Fourth Quarter

 Research And Development Spending Expected To Increase To Support Entry Into
                               Genomics Market

     Fourth Quarter Highlights
     -- Sales increase 44%
     -- Operating income increases 119%
     -- Continued balance sheet improvement in receivables, inventory and
        fixed assets

     Full-year Highlights
     -- Sales increased 45%
     -- Entered the genomics market with Discovery ISH system
     -- Competitive position strengthens in all geographic markets and product
        segments

    TUCSON, Ariz., Feb. 4 /PRNewswire/ -- Ventana Medical Systems, Inc.
(Nasdaq: VMSI); the leading company in supplying automated instrument reagent
systems to histology labs, today reported a 44% increase in sales for the
quarter ended December 31, 1999 compared to the same quarter last year, and
record earnings of $0.20 per share, before a one-time tax credit of
$5.5 million
    Net sales for the three months ended December 31, 1999 increased to
$21.1 million from $14.7 million for the same period in 1998.  Operating
earnings for the fourth quarter increased to $3.3 million, another record, and
a 119% increase over the $1.5 million reported in the same quarter of 1998
(before previously reported one-time acquisition related expenses of $3.2
million).  Net income for the fourth quarter of $8.4 million was impacted by a
$5.5 million tax gain that recognizes the value of the Company's deferred
taxes assets.  Without this one-time tax gain required by the Company's
auditors under FASB 109, diluted earnings per share were $0.20, and represent
an 82% increase over the same prior year period of $0.11 per share (before the
same previously reported acquisition-related expenses).  Diluted earnings per
share for the fourth quarter on an as reported basis were $0.57.
    "1999 was an outstanding year for Ventana on all fronts," reported Chris
Gleeson, president and chief executive officer.  "From a financial perspective
we continued to grow our revenues at better than a 40% rate compared to the
prior year.  We have begun to realize the leverage of our investments in R&D
and direct distribution by reporting record operating earnings.  From an
operational perspective, we strengthened our competitive position in all
geographic markets and product segments.  Our North American commercial
organization continued to enjoy rapid growth while our European and Japanese
commercial operations established clear leadership positions in their
respective markets.  International operations are now a significant
contributor to our revenues and profits."
    Gleeson continued, "We are no longer a one product company.  Our core
immunohistochemistry (IHC) business remains strong.  IHC placements during
1999 exceeded all competitors combined on a global basis.  We have established
a clear leadership position in automating special stains following the launch
of this second major instrument system in late 1998.  We successfully entered
the genomics market with the launch of the Discovery
in-situ hybridization (ISH) system late in the fourth quarter.  The system was
strongly received by DNA and gene chip companies, genomics companies and
academic research institutions.  We also significantly increased sales of our
tissue processor product line which was acquired during 1998."
    "In addition to delivering strong operating results during the fourth
quarter, we also made sound progress in strengthening our balance sheet,"
Gleeson added.  "Accounts receivable days sales outstanding decreased from 100
days at September 30, 1999 to 90 days at year-end.  Days-inventory-on hand
also fell modestly from 199 days on September 30, 1999 to 194 days at
year-end.  Net fixed assets declined by $1.3 million during the fourth quarter
due to our success in converting instruments at customer sites on an
evaluation basis into revenues."
    Net sales for the 12 months ended December 31, 1999 were $69.4 million, a
45% increase over the $47.7 million reported for 1998. Operating earnings for
1999 were $7.7 million, compared to $541,000 reported for 1998.  Diluted
earnings per share were $0.50 before the one-time $5.5 million tax credit.
This represents a 355% increase over $0.11 reported for 1998.  As reported,
diluted earnings per share were $0.88.
    Looking forward to the year 2000, Gleeson said, "We have established 2 key
strategic priorities - continuing to automate manual work cells in histology
labs with our IHC, special stain, ISH and tissue processing systems, and
establishing a foothold in the emerging Genomics market.  To support our entry
into the Genomics market we plan to increase R&D spending dramatically from
around 10% of revenues in 1999 to around 13% of revenues in 2000.  This
increased R&D spending could result in operating income being about $1.5
million lower than current analyst estimates for 2000.  However, this
investment in R&D will have a large payback in 2001 and beyond.  In addition,
we will be accruing income taxes in 2000 at a 40% rate due to the one-time
gain we booked this year."

    Safe Harbor Statement: Statements in this press release which are not
strictly historical are "forward-looking" statements that are made pursuant to
the Safe Harbor provisions of the Private Securities Litigation Reform Act of
1995.  Forward-looking statements involve known and unknown risks, which may
cause the company's actual results in the future to differ materially from the
expected results.  The risks and uncertainties that may affect the results of
the company's business may include general economic conditions, market
acceptance of new automated histology products, continued success in asset
management and other factors that are described in the company's specific
filings with the Securities and Exchange Commission.
    Ventana develops, manufactures and markets instrument/reagent systems that
automate tissue preparation and slide staining in histology laboratories
worldwide.  Ventana's systems are important tools used in the diagnosis and
treatment of cancer and infectious diseases.
    For more information on Ventana Medical Systems, Inc. via facsimile at no
additional cost, simply dial 1-800-PRO-INFO and enter the stock symbol "VMSI".


                        Ventana Medical Systems, Inc.
                    Consolidated Statements of Operations
                     (in thousands except per share data)
                                 (Unaudited)

                                               Three Months Ended:
                                            December 31               '99/'98
                                       1999            1998          %Change

    Sales:
     Instruments                       $9,490         $5,268            80%
     Reagents and other                11,560          9,391            23%
      Total net sales                  21,050         14,659            44%
    Cost of goods sold                  6,317          4,309            47%
    Gross profit                       14,733         10,350            42%
    Operating expenses:
     Research and development           1,846          1,031            79%
     Selling, general and
      administrative                    9,277          7,585            22%
    Nonrecurring expenses                   -          3,160              -
    Amortization of intangibles           284            217            31%
    Income from operations              3,326         (1,643)             -
    Other income                         (416)            23              -
    Pretax income                     $ 2,910        $(1,620)             -
    Provision for income tax           (5,500)             -              -
    Net income                        $ 8,410        $(1,620)             -



    Earnings per share as reported:
      Basic                             $0.62         $(0.12)             -
      Diluted                           $0.57         $(0.12)             -


    Earnings per share before
     provision for income tax:
      Basic                             $0.21         $(0.12)             -
      Diluted                           $0.20         $(0.12)             -


                        Ventana Medical Systems, Inc.
                    Consolidated Statements of Operations
                     (in thousands except per share data)
                                  (Audited)

                                        Twelve Months Ended
                                            December 31,             '99/'98
                                        1999       1998               % Change
    Sales:
     Instruments                      $24,069         $15,737           53%
     Reagents and other                45,340          31,967           42%
      Total net sales                  69,409          47,704           45%
    Cost of goods sold                 21,218          14,542           46%

    Gross profit                       48,191          33,162           45%
    Operating expenses:
     Research and development           7,078           5,057           40%
     Selling, general and
      administrative                   32,381          23,805           36%
    Nonrecurring expenses                   -           3,160             -
    Amortization of intangibles         1,051             599           75%
    Income from operations              7,681             541         1320%
    Other income                         (370)          1,089             -
    Pretax income                      $7,311          $1,630          349%
    Provision for income tax           (5,500)              -             -
    Net income                        $12,811          $1,630          686%


    Basic earnings per share            $0.95           $0.12          692%
    Diluted earnings per share          $0.88           $0.11          700%

    Note:  The consolidated income statements at December 31, 1999 and
           December 31, 1998 have been derived from the audited financial
           statements at those dates but do not include all of the information
           and footnotes required by generally accepted accounting principles
           for complete financial statements.


                        Ventana Medical Systems, Inc.
                         Consolidated Balance Sheets
                       (in thousands except share data)
                                  (Audited)

                             December 31,   December 31,  Inc/(Dec)
              ASSETS              1999         1998          $Amt        %

    Current assets:
     Cash and cash equivalents    $1,787      $ 2,424       (637)      -26%
     Accounts receivable          20,776       16,531       4,245       26%
     Inventories                  13,474       11,009       2,465       22%
     Prepaid expenses                831          645         186       29%
     Deferred tax benefit,
      current portion              1,450            -       1,450         -
     Other current assets          2,259        1,142       1,117       98%
    Total current assets          40,577       31,751       8,826       28%
    Property and equipment, net   14,441        9,937       4,504       45%
    Intangibles, net              14,178       14,592       (414)       -3%
    Deferred tax benefit,
     long term portion             4,885            -       4,885         -
    Total assets                 $74,081      $56,280     $17,801       32%


    LIABILITIES AND STOCKHOLDERS' EQUITY

    Current liabilities
     Accounts payable             $4,017      $ 3,536         481       14%
     Other current liabilities     6,965        5,053       1,912       38%
    Total current liabilities     10,982        8,589       2,393       28%
    Long term debt                 2,599        1,907         692       36%
    Stockholders' equity:
      Common stock - $.001 par value;
       50,000,000 shares authorized;
       13,614,246 and 13,421,819
       shares issued and outstanding
       at December 31, 1999 and
       December 31, 1998,
       respectively                   14           13           1        8%
     Additional Paid-In Capital   80,542       78,716       1,826        2%
     Accumulated deficit         (19,341)     (32,152)     12,811      -40%
     Cumulative foreign currency
      translation adjustment        (115)        (193)         78      -40%
     Treasury stock - 40,000
      shares, at cost               (600)        (600)          -         -
    Total stockholders' equity    60,500       45,784      14,716       32%
    Total liabilities and
     stockholders' equity        $74,081      $56,280     $17,801       32%

    Note:  The consolidated balance sheets at December 31, 1999 and
           December 31, 1998 have been derived from the audited financial
           statements at those dates but do not include all of the information
           and footnotes required by generally accepted accounting principles
           for complete financial statements


                        Ventana Medical Systems, Inc.
                    Consolidated Statements of Cash Flows
                                (in thousands)
                                 (Unaudited)

                                                   Twelve Months Ended
                                                      December 31
                                                   1999             1998
    Operating activities:
    Net income                                  $12,811            $1,630
    Adjustments to reconcile net income
     to cash provided by operating activities:
      Change in deferred tax benefit, net        (6,335)                -
      Depreciation and amortization               3,821             2,850
      Changes in operating assets and
       liabilities, net                          (6,331)           (7,024)
    Net cash provided by operating activities     3,966            (2,544)
    Investing activities:
    Purchase of property and equipment, net      (6,372)           (5,377)
    Purchase of intangible assets, net             (672)          (10,262)
    Net cash used in investing activities        (7,044)          (15,639)
    Financing activities:
    Issuance of debt - net                          692               (46)
    Issuance of stock - net                       1,827             1,803
    Net cash provided by financing activities     2,519             1,757
    Effect of exchange rate change on cash          (78)              (52)
    Net (decrease) increase in cash and
     cash equivalents                              (637)          (16,478)
    Cash and cash equivalents, beginning
     of period                                    2,424            18,902
    Cash and cash equivalents, end of period     $1,787            $2,424


SOURCE Ventana Medical Systems, Inc.




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CONTACT:
Christopher Gleeson, President and Chief
Executive Officer of Ventana Medical Systems, Inc., 520-887-2155;
or Analysts, Kathy Brunson, or Media Inquiries Darcy Bretz, of
The Financial Relations Board, 312-266-7800