PATROL UPLC Process Analyzer World's First UPLC PAT System, Tied Directly
to Increased Production Efficiency
NEW ORLEANS, March 3 /PRNewswire-FirstCall/ -- Driven by the vision of
scientists worldwide to address challenges that couldn't previously be
solved, Waters Corporation (NYSE: WAT) today unveiled new innovative
solutions at the 59th Pittsburgh Conference on Analytical Chemistry and
Applied Spectroscopy, March 2 - 6, 2008 in New Orleans that expand the
boundaries of its platform technologies.
Leading Waters' new offerings at Pittcon 2008 is the Waters(R)
PATROL(TM) UPLC(TM) Process Analyzer, a real-time liquid chromatography
(LC) online process analytical technology (PAT) system; the Waters
SYNAPT(TM) MS system, an upgradeable next-generation quadrupole orthogonal
acceleration (oa) time- of-flight (Tof) mass spectrometry (MS) platform;
and Waters SDMS(TM) VP's Intelligent Procedure Manager (IPM), a workflow
software package to guide analysts through laboratory procedures.
"Entering our 50th year of continuous operation, Waters consistently
ignites new cycles of innovation working alongside our customers and
partners," said Art Caputo, President of the Waters Division. "In 1963, Dow
Chemical approached Waters, at the time a boutique engineering firm, to
build a custom on-line refractor for process monitoring applications, which
in essences led to the first commercially available LC system. Today, we
see history repeating. Just like Dow approached Jim Waters for a custom
refractor, it was a leading pharmaceutical manufacturer who approached us
at a recent Pittcon meeting to discuss applying UPLC technology to process
analysis that led to the development of PATROL UPLC. We can't wait for the
next customer to come into our Pittcon 2008 booth with a problem to solve
or a vision to support."
QC Analysis on the Manufacturing Floor
The new Waters PATROL UPLC Process Analyzer is a real-time online
process analytical technology (PAT) system able to detect and quantify
complex multiple component manufacturing samples and final product on the
production floor.
Designed with the same enabling technology platform as Waters
ACQUITY(TM) Ultra-Performance Liquid Chromatography(TM) (UPLC) System, the
PATROL UPLC Process Analyzer moves existing liquid chromatography (LC)
analysis from off- line Quality Control (QC) laboratories directly to the
manufacturing stream resulting in significant improvements in production
efficiency with real-time analysis, reducing both process cycle times and
assuring product quality.
"Waters PATROL UPLC Process Analyzer creates a foundation of confidence
by enabling quantifiable, real-time, in-process analysis directly on the
manufacturing floor," said Craig Dobbs, Senior Manager Pharmaceutical
Business Operations for the Waters Division. "Liquid chromatography is the
'Gold Standard' for analytical testing because of its unmatched
selectivity, sensitivity, and dynamic range, combined with its unique
ability to resolve and quantify related and unrelated compounds. However,
until today LC has not been a viable PAT technique due to unacceptably long
analysis times needed for sufficient resolution, lack of efficient
automation, and the need for often complex data reduction and analysis.
Waters PATROL UPLC Process Analyzer analytical power and speed redefines
the PAT equation."
Waters is currently collaborating with several global pharmaceutical
companies to quantify the PATROL UPLC Process Analyzer's impact on the
manufacturing process. A goal of real-time PAT is to produce more product
with existing resources compared to a time-consuming, off-line QC process.
Early analysis supports that the PATROL UPLC Process Analyzer can enable
process recovery increases during major manufacturing steps, virtually
eliminating the need for any reprocessing. In general, increase in process
recovery results in increase yield, which in turn translates into higher
profits per batch.
Future-Proofing MS Laboratories
For the first time at Pittcon, Waters will display its new Waters
SYNAPT MS system, a next-generation quadrupole orthogonal acceleration (oa)
time-of- flight (Tof) mass spectrometry (MS) platform. SYNAPT MS is a key
part of Waters strategy to enhance the quality and productivity of life
science and drug discovery and development workflows.
Additionally, the SYNAPT MS system is the only platform which provides
a turn-key upgrade pathway to the SYNAPT High Definition MS(TM) (HDMS(TM))
system, uniquely enabling researchers to analyze samples differentiated by
size, shape and charge, as well as mass, ultimately providing new
capabilities that can help them meet and exceed their future requirements.
"Confident sample identification, detailed characterization and
increased productivity are primary requirements for intelligent mass
spectrometry based solutions in key biomedical applications; such as
proteomics, metabonomic profiling, biomarker discovery/validation and
pharmaceutical R&D," said Brian W. Smith, Vice President, Mass Spectrometry
Operations for the Waters Division. "The new SYNAPT MS meets these demands
through application specific system solutions designed to help our
customers accelerate and improve the quality of laboratory analysis with
the goal of advancing research and reducing time-to- market."
"A unique aspect of the SYNAPT MS System is that it is 'HDMS-ready.'
Our customers will be able to upgrade their systems to incorporate the
unique High Definition MS capabilities when they require more powerful
solutions to meet their future goals, effectively future-proofing their
laboratories," added Smith.
Automates and Integrates Method SOP
Waters Corporation today introduced Waters NuGenesis SDMS Intelligent
Procedure Manager, a workflow software package designed to guide a
laboratory analyst through a routine, comprehensive method standard
operating procedure (SOP) and integrate results with a chromatography data
system, such as Waters Empower 2 Chromatography Data Software.
Today, manual or paper-driven guidelines still dominate certain
laboratory functions, especially those functions focused on method or
analytical SOPs. For example, 1) instrument checks, 2) standards and sample
preparation, 3) solvent and mobile phase separation, 4) analyses review, 5)
result approval, and 6) final product release are all prone to time
inefficiency and data transcription errors because they depend on paper
guidelines.
"Expanding off of the industry's most popular and powerful
chromatography data measurement software, Waters Empower 2, and able to
connect to standard laboratory information management systems, Intelligent
Procedure Manager addresses the predominately manual activities required to
perform an analytical method or test," said Phil Kilby, Senior Manager,
Informatics Marketing for Waters Division. "Supporting a 'Right the First
Time' philosophy, Waters estimates potential reduction in cycle time using
Intelligent Procedure Manager compared to a traditional paper trail as high
as 50 percent, with fewer opportunities for errors."
From late stage development to final product quality control and lot
release, Intelligent Procedure Manager can be equally applied to any lab
environment where rigorous adherence to approved test methods and SOPs must
be followed, including compliance requirements for cGMP operations. All
primary laboratory data and metadata are quickly and easily acquired in
electronic form and stored in a secure, 21 CFR Part 11, cGMP-, GLP-
compliant database.
News Conference
Waters' Pittcon 2008 News Conference, featuring Rohit Khanna, Vice
President Marketing, and Mary Ellen Goffredo, Senior Director, Systems
Product Marketing, Waters Corporation will be held Monday, March 3rd, from
8:30 am- 9:30 am in the Ernest N. Morial Convention Center, Room 352.
Scientific Presentations
Waters will participate within Pittcon program with a variety of
oral/poster sessions and symposia that will provide the ideal environment
to share knowledge, expertise and the latest application approaches to
solving analytical challenges.
Waters will also host educational seminars given by leading scientists
in four categories, including but not limited to the following seminar
topics:
-- Mass Spectrometry
-- Trace Level Analysis of Contaminants in Drinking Water
-- Tools for Compound Identification and Characterization
-- Tandem Quadrupole MS
-- Improve Productivity with UPLC
-- Informatics / Software
-- Live Tutorials on Custom Fields and Reports
-- Extended Capabilities to Support MS Technologies
-- Streamline and Automate Workflows
-- Live demos on CDS focused and MS focused overviews
-- Sample Preparation
-- Introduction to SPE
-- SPE Strategies for Food Analysis
-- Troubleshooting Methods Using Polymeric Sorbents
-- Trace Level Analysis of Contaminants in Drinking Water
-- Chromatography (GC, UPLC, HPLC)
-- Method Transfer from HPLC to UPLC
-- The Chemistry of UPLC Technology
-- Robust Separations with UPLC Technology
-- Improve Analysis with UPLC
-- New LC Breakthrough Technology
-- Improve Productivity of your MS with UPLC
For more a information on Waters Patrol UPLC, SYNAPT MS, SDMS VP IPM,
or a schedule of Waters' education seminars at Pittcon 2008, please visit:
Waters booth #2639 or http://www.waters.com/pittcon.
About Waters Corporation
Waters Corporation creates business advantage for laboratory-dependent
organizations by delivering practical and sustainable innovation to enable
significant advancements in such areas as healthcare delivery,
environmental management, food safety, and water quality worldwide.
Pioneering a connected portfolio of separations science, laboratory
information management, mass spectrometry and thermal analysis, Waters
technology breakthroughs and laboratory solutions provide an enduring
platform for customer success.
With revenue of $1.47 billion in 2007 and 5,000 employees, Waters is
driving scientific discovery and operational excellence for customers
worldwide.
Waters, ACQUITY, UltraPerformance LC, UPLC, PATROL, Synapt, High
Definition MS, HDMS, and NuGenesis are trademarks of Waters Corporation.
Contact: Brian J. Murphy
Waters Corporation
Public Relations Manager
508-482-2614
Brian_J_Murphy@waters.com
SOURCE Waters Corporation
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Related links:
http://www.waters.com
http://www.waters.com/pittcon
CONTACT:
Brian J. Murphy, Public Relations Manager of
Waters Corporation, +1-508-482-2614, Brian_J_Murphy@waters.com
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