FREMONT, Calif., March 18 /PRNewswire-FirstCall/ -- Abgenix, Inc.
(Nasdaq: ABGX) today announced that Amgen has completed patient enrollment in
a pivotal trial evaluating panitumumab, an experimental fully human monoclonal
antibody, as monotherapy for metastatic colorectal cancer patients who have
failed standard chemotherapy. The randomized, controlled clinical trial,
which has enrolled more than 460 patients in Europe, Australia and Canada,
evaluates best supportive care plus panitumumab monotherapy administered every
other week versus best supportive care alone in patients with advanced
metastatic colorectal cancer who have failed previous therapies.
"We are delighted Amgen has completed enrollment in this rigorously
designed clinical trial, and await the study findings on the safety and
efficacy of panitumumab in patients with advanced colorectal cancer. We hope
to include the study as part of a potential BLA submission later this year,
data pending," said Gisela Schwab, M.D., chief medical officer at Abgenix.
"We look forward to the continued development of panitumumab and are working
with Amgen to bring this potential new therapy to patients with advanced
colorectal cancer."
About Panitumumab
Co-developed by Amgen and Abgenix, panitumumab is an investigational
product in a new class of targeted cancer treatments called epidermal growth
factor receptor (EGFr) inhibitors. Panitumumab (formerly ABX-EGF) is the
first fully human monoclonal antibody directed against EGFr and is being
evaluated as both a monotherapy and in combination with other agents for the
treatment of various types of cancer, including colorectal, lung and kidney.
Panitumumab is generated with XenoMouse(R) technology, which creates a fully
human monoclonal antibody that contains no murine (mouse) protein. The fully
human nature of panitumumab is being investigated for its potential to reduce
the incidence of infusion reactions and antigenicity, as well as reduce the
likelihood of allergic response, compared with chimeric antibodies
(monoclonal antibodies that contain murine protein).
About the Epidermal Growth Factor Receptor (EGFr)
Although EGFr normally helps regulate the growth of many different cells
in the body, EGFr can also stimulate cancer cells to grow. In fact, many
cancer cells actually require signals mediated by EGFr for their survival.
Residing on the surface of these tumor cells, EGFr is activated when naturally
occurring proteins in the body, epidermal growth factor (EGF) or transforming
growth factor alpha (TGF alpha), bind to it. This binding changes the shape
of EGFr, which, in turn, triggers internal cellular signals that stimulate
tumor cell growth.
Panitumumab binds to EGFr, preventing EGF and TGF alpha from binding to
the receptor and interfering with the signals that would otherwise stimulate
growth of the cancer cell and allow it to survive.
About Abgenix
Abgenix is a biopharmaceutical company focused on the discovery,
development and manufacturing of human therapeutic antibodies. The company's
antibody development platform includes a leading technology and
state-of-the-art manufacturing capabilities that enable the rapid generation,
selection and production of high affinity, fully human antibody product
candidates to a variety of disease targets. Abgenix leverages its leadership
position in human antibody technology to build a diversified product portfolio
through its own development efforts and the establishment of collaborations
with multiple pharmaceutical and biotechnology companies. For more information
on Abgenix, visit the company's website at http://www.abgenix.com.
Statements made in this press release about Abgenix's technologies,
product development activities, collaborative arrangements and process science
and manufacturing capabilities, other than statements of historical fact, and
about its projected financial results and the achievement of milestone or
similar payments, are forward-looking statements and are subject to a number
of uncertainties that could cause actual results to differ materially from the
statements made, including risks associated with the success of clinical
trials, the progress of research and product development programs, product
manufacturing, regulatory approval processes, competitive products and
services, future capital requirements and the extent and breadth of Abgenix's
patent portfolio. Please see Abgenix's public filings with the Securities and
Exchange Commission for information about risks that may affect Abgenix.
SOURCE Abgenix, Inc.
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Related links:
http://www.abgenix.com
CONTACT:
Ami Knoefler, Senior Director of Corporate
Communications and Investor Relations for Abegenix, Inc.,
+1-510-284-6350 or +1-510-284-6605
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