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Icoria Reports Q4 and Year-End Results

           Monsanto Transaction Spurs Focus on Health Care in 2005

    RESEARCH TRIANGLE PARK, N.C., March 24 /PRNewswire-FirstCall/ -- Biotech
company Icoria, Inc. (Nasdaq: ICOR), today announced record revenue of
$24.6 million in 2004, a 16 percent increase over 2003.
    The company reported revenue of $6.3 million for the fourth quarter of
2004 and a net loss of $4.1 million, or $0.11 per share.  The fourth quarter
results include a $1.9 million one-time write-off of intangible assets related
to the March 2004 acquisition of TissueInformatics.Inc.  Excluding the
write-off of intangible assets, the net loss for the fourth quarter would be
$2.2 million, or $0.06 per share.  Quarterly revenue declined from the record
third quarter of 2004 revenue of $7.1 million, but was 16 percent higher than
the fourth quarter of 2003.
    The net loss for 2004 was $14.4 million, or $0.40 per share, compared to
$12.2 million, or $0.38 per share for 2003.  Excluding the write-off of
intangible assets, the net loss for 2004 would be $12.5 million, or $0.35 per
share.  Expenses in 2004 grew as Icoria invested in its healthcare business,
including the TissueInformatics.Inc acquisition.
    As of December 31, 2004, the company had $9.6 million in unrestricted
cash, cash equivalents and short-term investments.

    Management Discussion
    "While we achieved record revenue in 2004, it was below our expectations,
largely due to a lack of new commercial activity in quantitative tissue
analytics," said Heinrich Gugger, Ph.D., President and CEO.  "Although the
TissueInformatics.Inc acquisition has proven valuable in our internal
discovery efforts, we failed to meet our external milestones.  It became clear
that additional market preparation and product development would be needed
before we could successfully market quantitative tissue analysis.  As a
result, we are writing off the intangible assets that relate to
TissueInformatics.
    "Despite the revenue shortfall, we closed the year within our projected
cash target of $9 to $10 million.  Our cash position will be bolstered by the
announcement today that we are selling selected agricultural assets to
Monsanto for $6.75 million in cash and other considerations in a deal that
will have a $15 million direct benefit to Icoria.  In addition to the cash
component, the transaction reduces our lease obligations by $5.2 million and
gives Icoria $3 million in net cash flow benefits from an amendment to the
existing Monsanto contract.  We also expect to see $4 million in annual
savings associated with lower general and administrative costs.
    "This agreement marks our transition out of the agricultural market and
creates a streamlined healthcare-focused biotechnology company.  We will
concentrate on biomarker-enabled drug discovery and our internal program to
discover and validate targets and potential drug candidates for the treatment
of diabetes, obesity and livery injury," concluded Gugger.

    Significant Fourth Quarter Activities
    During the fourth quarter of 2004, Icoria raised $5 million gross proceeds
through the sale of a three-year Secured Convertible Term Note ("Note") in a
private placement with The Laurus Master Fund, Ltd.  This note is payable in
cash or convertible into shares of Icoria's common stock at a fixed conversion
price of $0.53 per share beginning in May 2005.
    In December, Icoria moved from the Nasdaq National Market to the Nasdaq
Small Cap Market.  As a result of that move, and pursuant to the Rules of the
National Association of Securities Dealers, the Staff of the Nasdaq Stock
Market granted Icoria until June 2005 to bring its share price above the $1
minimum bid price required for listing on the Nasdaq SmallCap Market.
    Full text of these and other significant or newsworthy events are listed
in the news section of Icoria's web site at http://www.icoria.com/news.

    Conference Call Scheduled for 4:30 p.m.
    Icoria's management team will conduct a conference call and webcast today
at 4:30 p.m. ET to discuss the company's new direction and Icoria's year-end
results.  Interested participants should call 1-800-289-0496 or, for those
calling internationally, 1-913-981-5519.  The conference call ID number is
4676929.  Icoria encourages participants to dial in 10 minutes before the call
commences.
    The webcast can be accessed from Icoria's web site at
http://www.icoria.com by clicking on the Investor Relations link.  For those
unable to participate in the live call, replays of the call may be heard
online at http://www.icoria.com or by calling (U.S.) 1-888-203-1112 or
(International) 1-719-457-0820 until midnight, March 28, 2005.

    About Icoria
    Icoria, Inc. is a biotechnology company that uses gene expression,
metabolomics and tissue feature profiling to identify biomarkers to accelerate
drug discovery.  In addition to its internal drug discovery program, the
company provides services to clients in the pharmaceutical, biotech,
agriculture, academic and public health research sectors, and has major
contracts with the National Institute of Environmental Health Sciences and
Pioneer Hi-Bred International (a subsidiary of DuPont).  Icoria also has a
major grant from the National Institute of Standards & Technology's Advanced
Technology Program.  For more information, visit http://www.icoria.com .

    This press release contains forward-looking statements that include but
are not limited to the Company's expectations for its evolving business focus,
biomarker-enabled drug development platform and potential revenue growth.
Such forward-looking statements are based on management's current expectations
and are subject to a number of risks, factors and uncertainties that may cause
actual results, events and performance to differ materially from those
referred to in the forward-looking statements.  These risks, factors and
uncertainties include, but are not limited to Icoria's early stage of
development, history of net losses, technological and product development
uncertainties, reliance on research collaborations, uncertainty of additional
funding and ability to protect its patents and proprietary rights.  Certain of
these and other risks are identified in Icoria's annual report on Form 10-K
for the year ended December 31, 2003 and in its quarterly report on Form 10-Q
for the quarter ended September 30, 2004, each filed with the Securities and
Exchange Commission.  The Company does not intend to update any of the
forward-looking statements after the date of this release to conform these
statements to actual results or to changes in our expectations, except as may
be required by law.


                                 ICORIA, INC.
                      CONDENSED STATEMENTS OF OPERATIONS
                (In thousands, except earnings per share data)

                             Three Months Ended
                                 December 31,              Year Ended
                                 (Unaudited)               December 31,
                              2004         2003         2004         2003
    Revenues:
    Revenues from
     commercial and
     government contracts   $5,851       $4,829      $22,924      $19,085
    Grant revenues             466          637        1,655        2,046
    Total revenue            6,317        5,466       24,579       21,131

    Operating expenses:
    Research and development 6,178        5,971       26,733       24,489

    Selling, general and
     administrative          2,096        1,690       10,005        8,268

    Impairment of intangible
     assets                  1,875          ---        1,875         ---

    Total operating
     expenses               10,149        7,661       38,613       32,757

    Loss from operations    (3,832)      (2,195)     (14,034)     (11,626)

    Interest income (expense),
     net                      (263)         (36)        (436)        (492)

    Net loss from continuing
     operations             (4,095)      (2,231)     (14,470)     (12,118)

    Discontinued operations     21           23           53          (36)

    Net loss from continuing
     operations            $(4,074)     $(2,208)    $(14,417)   $ (12,154)

    Net loss per share -
     basic and diluted
    Loss from continuing
     operations             $(0.11)      $(0.07)     $ (0.40)     $ (0.38)

    Income (loss) from
     discontinued operations  0.00         0.00        (0.00)       (0.00)

    Net loss per common
     share                 $ (0.11)     $ (0.07)     $ (0.40)     $ (0.38)

    Weighted average
     common shares
     outstanding -
       basic and diluted    36,669       32,557       35,671       32,313



                                 ICORIA, INC.
                         CONDENSED BALANCE SHEET DATA
                                (In thousands)

                                                 December 31,   December 31,
                                                        2004           2003
    Assets:
    Cash, cash equivalents, short-term investments    $9,598        $16,285
    Other current assets                               3,416          4,005
      Total Current Assets                           $13,014        $20,290
    Property & equipment net                          14,516         17,337
    Other noncurrent assets                            1,740          1,827
    Total Assets                                     $29,270        $39,454
    Liabilities and Stockholders' Equity:
    Current liabilities                               13,689         16,094
    Long-term obligations                              4,802          3,846
    Stockholders' equity                              10,779         19,514
    Total Liabilities and Stockholders' Equity       $29,270        $39,454


                                 ICORIA, INC.
 Supplemental Information Re:  Increase/(Decrease) in Cash, Cash Equivalents,
            Short-Term and Long-Term Investments (See Note Below)
                                 (Unaudited)
                                (In thousands)

                           Three Months Ended            Year Ended
                              December 31                December 31
                            2004       2003          2004           2003
    Net cash provided by
     (used in) operating
     activities           $(1,034)       $64       $(6,947)       $(5,441)

    Net cash (used in)
     provided by investing
     activities, excluding
     purchases and maturities
     of short-term and
     long-term investments   (299)       (83)          907           (325)

    Net cash provided by
     (used in) financing
     activities             3,844        275          (647)           819

    Net increase (decrease)
     in cash, cash equivalents,
     short-term investments
     and long-term
     investments            2,511        256         (6,687)       (4,947)

    Cash, cash equivalents,
     short-term investments
     and long-term
     investments,
     beginning of period    7,087     16,029         16,285        21,232

    Cash, cash equivalents,
     short-term
     investments and
     long-term investments,
     end of period         $9,598    $16,285         $9,598       $16,285

    Note:  The above presentation of the change in cash and investments is not
meant to be in accordance with generally accepted accounting principles
("GAAP") in the United States.  GAAP requires the presentation of a statement
of cash flows only (i.e., excluding changes in short and long-term
investments). In order to fully assess the Company's liquidity position,
management believes that the cash flow measure presented above, which includes
short-term and long-term investments, is an appropriate measure for evaluating
the Company's liquidity, because this reflects all liquid resources available
for strategic opportunities including, among others, to invest in the business
and continue operating activities. However, this measure should be considered
in addition to, and not as a substitute for, or superior to, cash flows
prepared in accordance with GAAP in the United States.
    Under GAAP, cash flows from investing activities above would improve by
net maturities of investment securities and unrealized gains and losses on
investments in the amount of $3.1 million and $0.07 million for the three
months ended December 31, 2004 and 2003, respectively, and by $9.2 million and
$6.2 million for the twelve months ended December 31, 2004 and 2003,
respectively. Also under GAAP, cash and cash equivalents at the beginning and
end of the period would be less, as they would exclude short and long-term
investments of $3.0 million and $9.2 million, and zero and $19.2 million for
the three months ended December 31, 2004 and 2003, respectively and by
$9.1 million and $15.3 million, and zero and $36.8 million for the twelve
months ended December 31, 2004 and 2003, respectively. Cash, cash equivalents,
short-term and long-term investments exclude restricted cash.


SOURCE Icoria, Inc.




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