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Agouron Reports Third Quarter 1998 Net Income

    LA JOLLA, Calif., April 14 /PRNewswire/ -- Agouron Pharmaceuticals, Inc.
(Nasdaq: AGPH) today announced net income of $13,525,000, or $.41 per share,
on total revenues of $134,458,000 for the quarter ended March 31, 1998.  Prior
year results for the same period were a net loss of $4,999,000, or $.18 per
share, on total revenues of $38,613,000.  Current quarter results include one-
time revenues of $12,000,000 ($.22 per share) from meeting certain product
approval milestones.  Sales of the Company's anti-HIV drug VIRACEPT(R)
(nelfinavir mesylate) in the third quarter were $111,950,000, including
$92,806,000 in U.S. sales -- a 10% increase from the immediately preceding
quarter.
    "Since VIRACEPT was cleared for marketing by FDA in March 1997, United
States sales have totaled over $308 million through March 31, 1998," said
Peter Johnson, president and chief executive officer.  "We believe that the
anti-HIV potency, durability, safety, and tolerability of VIRACEPT has
distinguished the product in the United States as an important element in the
arsenal of anti-HIV drugs."  VIRACEPT was also recently approved for marketing
in both Europe and Japan and is now approved for marketing in 26 countries.
    Agouron Pharmaceuticals, Inc. is an integrated pharmaceutical company
committed to the discovery, development, manufacturing, and marketing of
small-molecule drugs engineered to inactivate proteins which play key roles in
cancer, AIDS, and other serious diseases.
    VIRACEPT is indicated for the treatment of HIV infection when
antiretroviral therapy is warranted.  This indication is based on analyses of
surrogate marker changes in patients who received VIRACEPT in combination with
nucleoside analogues or alone for up to 24 weeks.  At present, there are no
results from controlled trials evaluating the effect of therapy with VIRACEPT
on clinical progression of HIV infection, such as survival or the incidence of
opportunistic infections.
    The most commonly observed adverse event of moderate or greater severity
in clinical trials of VIRACEPT was diarrhea, which was generally controlled
with over-the-counter medications.  New onset or exacerbation of diabetes
mellitus and hyperglycemia, as well as increased bleeding in patients with
hemophilia types A and B, have been reported with protease inhibitors.

    This press release may contain forward-looking statements or predictions.
These statements represent our judgment as of this date and are subject to
risks and uncertainties that could cause the actual results to differ
materially.  Important factors concerning these risks are discussed in our
Form 10-K for the fiscal year ended June 30, 1997 currently on file with the
Securities and Exchange Commission.

    For more information on Agouron, you may visit the Agouron Web Site at:
http://www.agouron.com.

    VIRACEPT(R) is a registered trademark of Agouron Pharmaceuticals, Inc.


                   CONSOLIDATED STATEMENT OF INCOME (LOSS)
                                 (Unaudited)
                   (In thousands, except per share amounts)

                                 Three Months Ended       Nine Months Ended
                                       March 31,              March 31,
                                  1998         1997        1998       1997
    Revenues:
      Product sales             $111,950     $13,401     $283,252   $13,401
      Contracts                    8,608      16,212       31,073    48,835
      License fees and royalties  13,900       9,000       16,652     9,000
                                 134,458      38,613      330,977    71,236

    Operating expenses:
      Cost of product sales       49,220       6,023      121,235     6,023
      Research and development    31,859      28,431       89,113    81,367
      Selling, general and
       administrative             14,168      10,280       40,759    19,802
      Royalties                   18,081           0       46,889         0
                                 113,328      44,734      297,996   107,192

    Operating income (loss)       21,130     (6,121)       32,981  (35,956)

    Other income (expense):
      Interest and other income    1,624       1,441        4,393     4,965
      Interest expense             (212)        (13)        (579)      (93)
                                   1,412       1,428        3,814     4,872

    Income (loss) before
     income taxes                 22,542     (4,693)       36,795  (31,084)

    Income tax provision           9,017         306       14,718       918

    Net income (loss)            $13,525    $(4,999)      $22,077 $(32,002)

    Earnings (loss) per share:
      Basic                         $.44     $ (.18)        $ .73   $(1.21)
      Diluted                       $.41     $ (.18)        $ .66   $(1.21)

    Shares used in calculation of:
      Basic                       30,757      27,230       30,414    26,478
      Diluted                     32,956      27,230       33,251    26,478


                          CONSOLIDATED BALANCE SHEET
                                (In thousands)

                                              March 31,        June 30,
                                                 1998            1997
                                             (Unaudited)      (Audited)
    Assets:
     Cash, cash equivalents and
      short term investments                  $116,946         $91,317
     Accounts receivable, net                   55,940          31,375
     Inventories                                91,000          58,800
     Current deferred tax assets                 1,654             500
     Other current assets                        2,777           2,209
        Total current assets                   268,317         184,201

     Property and equipment, net                40,998          22,613
     Deferred tax assets                        52,011          56,000
     Purchased intangibles                       3,650           4,100

                                              $364,976        $266,914

    Liabilities and stockholders' equity:
     Accounts payable and accrued liabilities  $85,835         $37,722
     Deferred revenue and advances              32,379          27,567
     Current deferred tax liabilities              154             600
     Loan payable and current portion of
     long-term debt                              3,530           2,526
        Total current liabilities              121,898          68,415

     Long-term debt, less current portion        5,330           5,940
     Accrued rent                                1,085           1,277
     Stockholders' equity                      236,663         191,282
                                              $364,976        $266,914

    Shares outstanding                          30,854          29,430



SOURCE Agouron Pharmaceuticals, Inc.




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    CONTACT:
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    Corporate Communications, 619-622-3009 or Media: Joy Schmitt,
    Manager of Product Public Relations, 619-622-3220 both of Agouron
    Pharmaceuticals, Inc.