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Ventana Medical Systems, Inc. Reports First Quarter Results

              Revenues and Operating Income Increase 14% and 8%,
                Respectively, Over First Quarter 1999 Figures

    TUCSON, Ariz., April 24 /PRNewswire/ -- Ventana Medical Systems, Inc.
(Nasdaq: VMSI); the leading company in supplying automated instrument-reagent
systems to histology labs, today  reported a 14% increase in sales for the
quarter ending March 31, 2000 compared to the same quarter last year, an 8%
increase in operating income and diluted earnings per share of $0.06.
    Net sales for the 3 months ended March 31, 2000 increased to $17.8 million
from $15.6 million for the same period in 1999.  Gross margins for the first
quarter came in at 66%, R&D expenses at 11% of sales and SG&A expenses at
45% of sales.  Operating earnings for the quarter increased to $1.5 million
over the $1.4 million reported in the same quarter of 1999.  Net income for
the first quarter declined to $969,000 from $1.2 million in the first quarter
of 1999 due to higher tax accrual rate.  The income tax accrual rate for the
first quarter of 2000 was 32% compared to 10% in the same quarter of 1999.
Reported diluted earnings per share for the first quarter were $0.06 compared
to $0.09 in the same quarter of 1999 due to both lower net income and an
increase in the number of diluted shares outstanding.
    "Our first quarter results were in line with expectations and came after
an exceptionally strong fourth quarter of 1999," commented Chris Gleeson,
Ventana's President and Chief Executive Officer.  "We are on track to report
revenue growth for the calendar year that should be at least a 30% increase
over 1999," Gleeson noted.  "A sales force realignment and training programs
impacted our North American revenues in the first quarter while our
international operations continued to grow rapidly.  We expect the investments
we have made in our North American organization to result in more rapid
revenue growth for the balance of the year."
    Looking forward to the balance of the year 2000, Gleeson noted, "Momentum
in our core histology business will continue to build with at least three
major product introductions planned over the next 12 months.  We are expecting
Food and Drug Administration pre-market approval during the second half of the
year of our CB11 antibody that physicians could use in deciding whether
metastatic breast cancer patients should receive Herceptin(R).  In addition,
the market launch of our clinical in-situ hybridization system is on track for
the fourth quarter.  We also expect to launch an automated imaging system for
quantitating IHC stains in the first quarter of next year.  Further, the
market opportunity for our Discovery system in the drug discovery (genomics)
market continues to expand.  We plan to formally launch the system in North
America in the second quarter and continue to enjoy strong interest in the
product in Japan."
    Safe Harbor Statement: Statements in this press release which are not
strictly historical are "forward-looking" statements that are made pursuant to
the Safe Harbor provisions of the Private Securities Litigation Reform Act of
1995.  Forward-looking statements involve known and unknown risks, which may
cause the company's actual results in the future to differ materially from the
expected results.  The risks and uncertainties that may affect the results of
the company's business may include general economic conditions, market
acceptance of new automated histology products, continued success in asset
management and other factors that are described in the company's specific
filings with the Securities and Exchange Commission.
    Ventana develops, manufactures and markets instrument/reagent systems that
automate tissue preparation and slide staining in histology laboratories
worldwide.  Ventana's systems are important tools used in the diagnosis and
treatment of cancer and infectious diseases.
    For more information on Ventana Medical Systems, Inc. via facsimile at no
additional cost, simply dial 1-800-PRO-INFO and enter the stock symbol "VMSI."


                        Ventana Medical Systems, Inc.
                    Consolidated Statements of Operations
                     (in thousands except per share data)
                                 (Unaudited)

                                        Three Months Ended:
                                              March 31               '00/'99
                                    2000        1999        B/(W)    % Change
    Sales:
      Instruments                $ 5,828       $ 5,120       $ 708      14%
      Reagents and other          12,001        10,512       1,489      14%
        Total net sales           17,829        15,632       2,197      14%
    Cost of goods sold             6,134         4,988       1,146      23%

    Gross profit                  11,695        10,644       1,051      10%
    Operating expenses:
      Research and development     1,984         1,629        (355)     22%
      Selling, general
        and administrative         7,960         7,399        (561)      8%
    Amortization of intangibles      278           253         (25)     10%
    Income from operations         1,473         1,363         110       8%
    Other income (expense)           (48)           24         (72)   -300%
    Pretax income                $ 1,425       $ 1,387        $ 38       3%
    Provision for income tax         456           138        (318)    230%
    Net income                     $ 969       $ 1,249      $ (280)    -22%

    Per Share Data:
    Basic earnings per share      $ 0.07        $ 0.09    $ (0.02)     -22%
    Diluted earnings per share    $ 0.06        $ 0.09    $ (0.03)     -33%

    Outstanding Shares:
    Basic                         14,305        13,404
    Diluted                       16,467        14,578


                          Ventana Medical Systems, Inc.
                            Consolidated Balance Sheet
                         (in thousands except share data)
                                   (Unaudited)

                                 March 31,  December 31,  Inc/(Dec)
        ASSETS                     2000         1999        $ Amt       %

    Current assets:
      Cash and cash equivalents $ 46,569       $ 1,787      44,782    2506%
      Accounts receivable         21,147        20,776         371       2%
      Inventories                 14,072        13,474         598       4%
      Prepaid expenses               802           574         228      40%
      Deferred tax benefit,
        current portion            1,434         1,692        (258)    -15%
      Other current assets           439           722        (283)    -39%
    Total current assets          84,463        39,025      45,438     116%
    Property and equipment, net   14,346        14,441         (95)     -1%
    Intangibles, net              15,148        14,178         970       7%
    Other Assets                   2,688         1,084       1,604     148%
    Deferred tax benefit,
      long term portion            4,433         4,433           -        -
    Total assets               $ 121,078      $ 73,161    $ 47,917      65%


        LIABILITIES AND STOCKHOLDERS' EQUITY

    Current liabilities
      Accounts payable           $ 2,782       $ 4,017      (1,235)    -31%
      Other current liabilities    5,660         6,600        (940)    -14%
    Total current liabilities      8,442        10,617      (2,175)    -20%
    Long term debt                 1,823         2,044        (221)    -11%
    Stockholders' equity:
      Common stock - $.001 par
       value; 50,000,000 shares
       authorized; 15,060,017 and
       13,593,640 shares issued
       and outstanding at
       March 31, 2000 and
       December 31, 1999,
       respectively                   15            14           1       7%
      Additional
        Paid-In Capital          129,855        80,542      49,313      61%
      Accumulated deficit        (18,372)      (19,341)        969      -5%
      Cumulative foreign currency
        translation adjustment       (85)         (115)         30     -26%
      Treasury stock - 40,000
        shares, at cost             (600)         (600)          -        -
    Total stockholders' equity   110,813        60,500      50,313      83%
    Total liabilities and
      stockholders' equity     $ 121,078      $ 73,161    $ 47,917      65%


                          Ventana Medical Systems, Inc.
                      Consolidated Statements of Cash Flows
                                  (in thousands)
                                   (Unaudited)

                                                          Three Months Ended
                                                               March 31
                                                            2000      1999
    Operating activities:
    Net income                                               $ 969  $ 1,249
    Adjustments to reconcile net income
     to cash provided by operating activities:
      Change in deferred tax benefit, net                      258        -
      Depreciation and amortization                          1,286      893
      Changes in operating assets and liabilities, net      (4,545)      61
    Net cash provided by operating activities               (2,032)   2,203

    Investing activities:
    Purchase of property and equipment, net                 (1,024)  (2,885)
    Purchase of intangible assets, net                      (1,250)     (45)
    Net cash used in investing activities                   (2,274)  (2,930)

    Financing activities:
    Repayment of debt - net                                   (256)     (64)
    Issuance of stock - net                                 49,314      480
    Net cash provided by financing activities               49,058      416

    Effect of exchange rate change on cash                      30        -

    Net (decrease) increase in cash and cash equivalents    44,782     (311)

    Cash and cash equivalents, beginning of period           1,787    2,424
    Cash and cash equivalents, end of period              $ 46,569  $ 2,113


SOURCE Ventana Medical Systems, Inc.




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CONTACT:
Christopher Gleeson, President and Chief
Executive Officer of Ventana Medical Systems, 520-887-2155,
Analysts, Kathy Brunson, or Media, Darcy Bretz, both of The
Financial Relations Board, 312-266-7800