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Trega Biosciences Reports First-Quarter Results; Revenues Increase 75%

    SAN DIEGO, Calif., May 4 /PRNewswire/ -- Trega Biosciences, Inc.
(Nasdaq: TRGA) today reported that revenues for its first quarter ending
March 31, 1999 increased approximately seventy-five percent to $2.1 million.
This compares with revenues of $1.2 million for the same period in 1998.
Increased revenues in the first quarter resulted from sales of the Company's
Chem.Folio(TM) combinatorial libraries and sales through Trega's wholly owned
subsidiary, NaviCyte, Inc., acquired in November 1998, as well as revenues
from research conducted under new and existing collaborative agreements.
    The net loss for the first quarter of 1999 was $2.7 million, or $0.15 per
share, compared with a net loss of $3.4 million, or $0.25 per share, in the
comparable period in 1998.  Included in other income in the first quarter of
1999 is a gain of $1.5 million on the sale of the assets of Trega's wholly
owned subsidiary, ChromaXome Corporation.  Revenues were not recognized in
connection with this sale.
    "We are pleased with our accomplishments in the first quarter," said
Michael G. Grey, president and chief executive officer.  "We achieved a major
milestone in our melanocortin research program with the announcement that
Trega's lead compound, HP 228, significantly reduced post-surgical pain in a
Phase II clinical trial."
    "We also added two new members, Schering-Plough and R.W. Johnson
Pharmaceutical Research Institute, to NaviCyte's predictive bioinformatics
Consortium, IDEA(TM), where they join SmithKline Beecham, Genentech and
Parke-Davis.  NaviCyte is in the advanced stages of producing a physiological
model of absorption utilizing clinical data provided by Consortium members,"
Mr. Grey continued.  "Finally, Trega sold substantially all its assets in
ChromaXome Corporation to TerraGen Diversity, Inc. in order to stay focused on
our core business strengths -- drug discovery, selection and early stage
development of novel drug therapies."
    Research and development expenses increased to $4.6 million in the first
quarter of 1999, compared with $3.6 million in the same quarter last year.
The increase in expenses was due to increased funding of Chem.Folio(TM) and
external drug discovery programs as well as the addition of research expenses
of NaviCyte.  Selling, general and administrative expenses increased to
$1.8 million, compared with $1.2 million for the same period last year.  Trega
ended the quarter with approximately $11.7 million in cash, cash equivalents
and short-term investments.
    Trega Biosciences is focused on accelerating the process of drug discovery
from disease targets to clinical candidates by using small molecule
combinatorial chemistry, high throughput screening and predictive
bioinformatics to rapidly create novel drug candidates having greater chances
of clinical success.  In combination with its wholly owned subsidiary,
NaviCyte, Trega offers integrated products and services spanning the drug
discovery process -- beginning with synthesizing novel compounds to providing
uniquely qualified drug leads -- to the pharmaceutical and biopharmaceutical
industries.  Trega also uses its drug discovery technologies in its internal
development programs, which are focused on discovering small molecules acting
on melanocortin receptors, which may be important in the treatment of
inflammatory and metabolic diseases.

    Except for the historical information contained herein, the matters
discussed in this news release are forward-looking statements that involve
risks and uncertainties, including whether the results reported are indicative
of future results, whether the Company's resources are sufficient to enable it
to reach its business objectives, whether any research to be conducted as
described will be successful, whether any additional collaborations or
alliances will be agreed to, formed or expanded, whether regulatory approvals
can be obtained for products discovered and developed, if any, whether any
such products can be successfully marketed, the impact of competitive products
and pricing, in marketing success, whether any other corporate collaborations
or alliances will be successful, and other risks detailed from time to time in
Trega's Securities and Exchange Commission filings.  These forward-looking
statements represent Trega's judgment as of the date of this release. Actual
results may differ materially from those projected.  Trega disclaims, however,
any intent or obligation to update these forward-looking statements.

    Trega's releases are on the World Wide Web at http://www.trega.com and PR
Newswire's fax-on-demand service at 1-800-758-5804, extension 374050.


                             TREGA BIOSCIENCES, INC.
                      Condensed Consolidated Balance Sheets
                      (in thousands, except per share data)

                                          March 31,       December 31,
                                            1999              1998
    ASSETS                              (unaudited)
      Current assets:
        Cash, cash equivalents
         and short-term investments        $ 11,676           $ 16,262
        Accounts receivable and
         other current assets                 1,338                778
      Total current assets                   13,014             17,040
      Property and equipment, net             3,756              4,123
      Other assets                            8,138              8,372
      Total assets                         $ 24,908           $ 29,535

    LIABILITIES AND STOCKHOLDERS'
     EQUITY
      Current liabilities:
        Accounts payable                      $ 794            $ 1,539
        Accrued compensation &
         other accrued liabilities            2,637              2,399
        Current portion of debt
         obligations                          1,160              1,251
        Deferred revenue                      2,454              3,794
      Total current liabilities               7,045              8,983
      Debt obligations                        2,693              2,912
      Total liabilities                       9,738             11,895

      Stockholders' equity:
        Common stock                             18                 18
        Additional paid-in capital           86,690             86,645
        Common stock issuable                    16                 16
        Deferred compensation, net             (444)              (609)
        Accumulated deficit                 (71,110)           (68,430)
      Total stockholders' equity             15,170             17,640
      Total liabilities and
       stockholders' equity                $ 24,908           $ 29,535


                             TREGA BIOSCIENCES, INC.
                  Condensed Consolidated Statement of Operations
                      (in thousands, except per share data)

                                                 Three Months Ended
                                                       March 31,
                                               1999               1998
                                                     (unaudited)
    Revenues:
      Contract research and
       license fees                         $ 2,030            $ 1,168
      Net sales                                 105                 --

    Total revenues                            2,135              1,168

    Operating expenses:
      Cost of sales                              59                 --
      Research and development                4,587              3,575
      Selling, general and
       administrative                         1,796              1,169

    Total operating expenses                  6,442              4,744

    Loss from operations                     (4,307)            (3,576)

    Other income:
      Interest income (expense), net            114                155
      Gain on sale of CXC                     1,513                 --

    Net loss                               $ (2,680)          $ (3,421)

    Basic and diluted net loss
     per share                              $ (0.15)          $ (0.25)

    Shares used in computing
     basic and diluted net loss
     per share                               17,853             13,910


SOURCE Trega Biosciences, Inc.




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    CONTACT:
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    Trega, 619-410-6695