Breakthrough Drug Candidates That Could Change the Way Alzheimer's
and AIDS Patients Are Treated
BIO 2003 is the Largest Gathering of Biotechnology Leaders in the World and
Has Emerged as the Single Most Important Forum for Bringing Players Together
WASHINGTON, June 23 /PRNewswire-FirstCall/ -- Samaritan Pharmaceuticals
Inc. (OTC Bulletin Board: SPHC) and Samaritan Research Labs, Georgetown
University, announced today it has scheduled numerous one on one meetings with
top pharmaceutical Companies throughout the BIO 2003 "Thinking Beyond
Tomorrow" Convention, June 22-25, 2003, Washington, DC. The annual convention
expects to draw over 15,000 biotechnology executives, politicians, scientists
and reporters. The Business Partnering Forum gives Samaritan an extraordinary
opportunity to meet with major pharmaceuticals around the world, in one place
and at one time, to learn about each other and discuss business opportunities
of mutual interest for potential partnering deals.
Promising Alzheimer's Drug Candidates Being Presented
Background for Alzheimer's thesis: Cortisol, the stress hormone, is the
main hormone associated with immunity, memorization and learning with
excessive cortisol being well known to produce cognitive impairment.
Why do we care: It is estimated that 16 million Americans will be
diagnosed with Alzheimer's by 2050. Early diagnosis and treatment with
Cortisol modulating drugs before the onset of symptoms could possibly lengthen
the progression of Alzheimer's whereas a patient might die of natural causes
rather than Alzheimer's.
Promising Alzheimer's Drug Candidates:
-- SP001
-- SP010
-- SP222
-- SP223
-- SP232
-- SP238
Patent Title:
-- Neuroprotective spirostenol pharmaceutical compositions.
-- Methods and compositions for modulating serum cortisol levels.
Journals:
-- Journal of Neurochemistry, 2002, 83:1110-1119
-- Endocrine Society 2003, abstract.
Stem Cell Therapy for Alzheimer's, Neuron Differentiation
Background: Stem cell therapy, the manipulation of stem cells to combat
disease, is on the threshold of a new era in medicine. Neuronal stem cells
can be induced to rapidly differentiate to adult neuron cells as a novel
treatment for Alzheimer's.
Promising Stem Cell Drug Candidates:
-- SP222b
-- SP237
New Alzheimer's Pharmacologic (Rat) Model Tool:
Brand New Tool-Used by pharmaceuticals to test their preventive,
stabilizing or curative therapies under development for Alzheimer's.
Advantage: Pharmacologic. Only four weeks to induce full blown Alzheimer's
disease compared to lengthy transgenics.
Alzheimer's Predictive Diagnostic:
Advantage: Simple blood test with 70% success rate.
Patent Title:
-- Neurosteroids: Markers of Alzheimer's disease pathology
Journals:
-- Neurobiology of Aging, 2003, 24:57-65.
AIDS Related Dementia Research and Drug Candidates
Background: Elevated cortisol levels are associated with many disease
states of which AIDS Related Dementia is included. SP001 has proven to be a
safe and effective cortisol modulator; therefore, SP001 and its bioequivalents
could change the way patients are treated, either as a single agent or in
combination with other conventional therapies for AIDS.
Promising AIDS and Related Dementia Drug Candidates:
-- SP001
-- SP010
-- SP014
-- SP016
-- SP017
Patent Titles:
-- Protected Complex of Procaine .......
-- Composition of Anti-HIV Drugs and Anticortisol Compounds ..........
-- Methods and Compositions for Modulating Serum Cortisol Levels ....
Proof of Concept HIV FDA Phase II Study Results
-- Safe, Tolerable, CD8 improvement, Cortisol modulation.
-- Statistically Significant
1. Decreased HIV symptoms (Whalen Scale-Quality of Life)
2. Decreased viral load.
-- Orphan drug status requested
"We have yet to meet a Pharma executive who wasn't impressed with our
science pipeline," commented Dr. Janet Greeson, Chairman, President and CEO of
Samaritan. "We have a compelling story to present and the climate for
partnering deals is warming up with a keener focus on new drug products and
new ways to attack disease."
(Photo: http://www.newscom.com/cgi-bin/prnh/20030129/SPHCLOGO )
About Samaritan Pharmaceuticals
Samaritan Pharmaceuticals, in collaboration with Georgetown University, is
working to commercialize superior new drugs that improve the quality of life
and overall health of suffering patients. The Company's compelling platform
technology is based on the stress hormone cortisol and its modulation. The
current development programs focus on promising new neuroprotective drugs for
memory loss and Alzheimer's and include "significant" positive results for its
HIV FDA/Phase II clinical trial; an Alzheimer's rat model to test new drugs;
an Alzheimer's Theragnostic; a Breast Cancer Theragnostic; and a Cholesterol
binding Peptide.
Disclaimer
The company disclaims any information that is created by an outside party
and endorses only information that is communicated by its press releases,
filings and Web site. This news release contains forward-looking statements
that reflect management's current beliefs about the potential for its drug
candidates, science and technology. However, as with any biopharmaceutical
under development, there are significant risks and uncertainties in the
process of development and regulatory review. There are no guarantees that
products will prove to be commercially successful. For additional information
about the factors that affect the company's business, please read the
company's latest Form 10-K filed May 15, 2003. The company undertakes no duty
to update forward-looking statements.
Contact: Samaritan Pharmaceuticals, Inc., 702/735-7001, Fax 702/737-7016
Gene Boyle, Business Development, Email GeneBoyle@aol.com
Doug Bessert, Investor Relations, Email DougBessert@aol.com
To receive future press releases and newsletters automatically, or for
more information, visit our Web site at http://www.samaritanpharmaceuticals.com .
SOURCE Samaritan Pharmaceuticals Inc.
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Related links: http://www.samaritanpharma.com
Photo Notes: NewsCom: http://www.newscom.com/cgi-bin/prnh/20030129/SPHCLOGO AP Archive: http://photoarchive.ap.org PRN Photo Desk, +1-888-776-6555 or +1-212-782-2840
Company News On-Call: http://www.prnewswire.com/comp/158311.html
CONTACT: Gene Boyle, CFO of Samaritan Pharmaceuticals Inc., +1-702-735-7001, or +1-702-499-8652, fax +1-702-737-7016, GeneBoyle@aol.com
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