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Agouron Reports 1998 Net Income; Announces Intention to Create Separate Oncology Division

    LA JOLLA, Calif., July 21 /PRNewswire/ -- Agouron Pharmaceuticals, Inc.
(Nasdaq: AGPH) today announced fiscal 1998 net income of $13,154,000, or $.40
per share, on total revenues of $466,505,000.  Fiscal 1998 sales of the
company's anti-HIV drug VIRACEPT(R) (nelfinavir mesylate) were $409,298,000
which included sales in the United States of $358,321,000.  Fourth quarter
VIRACEPT sales in the United States were $105,633,000.  Total VIRACEPT sales
in the fourth quarter were $126,046,000, a 13% increase from the immediately
preceding quarter.  The fourth quarter net loss of $8,923,000, or $.29 per
share, reflected the company's payment of licensing fees of $26,000,000 for
three development-stage anti-HIV products.  Prior to such license fees and
related costs, fourth quarter and annual fiscal 1998 net income was $7,222,000
or $.22 per share and $29,659,000 or $.89 per share, respectively.  Prior year
results for the fourth quarter and fiscal year were, respectively, net losses
of $10,804,000 ($.38 per share) and $42,806,000 ($1.59 per share) on total
revenues of $60,827,000 and $132,063,000.
    The company also announced its intention to create a separate operating
division in which the company's research and development of products for
oncology and related fields will be conducted.  Under the proposed plan, which
must be approved by the company's shareholders, the financial performance of
this oncology R&D division would be tracked by a separate divisional stock.
    "With this plan to separately monitor the financial performance of our
oncology R&D group, we are pursuing two objectives," said Peter Johnson,
Agouron's president and chief executive officer.  "First, we seek to unlock
what we believe to be the largely unappreciated value of our R&D pipeline of
products for oncology and related fields.  Second, we seek to sustain the
potential for earnings growth from our VIRACEPT-driven antivirals business
without compromising our vigorous investment in new product opportunities."
     Agouron Pharmaceuticals, Inc. is an integrated pharmaceutical company
committed to the discovery, development, manufacturing, and marketing of
innovative therapeutic products engineered to inactivate proteins that play
key roles in cancer, AIDS, and other serious diseases.

    For more information on Agouron, you may visit the Agouron Web Site at
http://www.agouron.com.

    VIRACEPT is indicated for the treatment of HIV infection when
antiretroviral therapy is warranted.  This indication is based on analyses of
surrogate marker changes in patients who received VIRACEPT in combination with
nucleoside analogues or alone for up to 24 weeks.  At present, there are no
results from controlled trials evaluating the effect of therapy with VIRACEPT
on clinical progression of HIV infection, such as survival or the incidence of
opportunistic infections.
    The most commonly observed adverse event of moderate or greater severity
in clinical trials of VIRACEPT was diarrhea, which was generally controlled
with over-the-counter medications.  New onset or exacerbation of diabetes
mellitus and hyperglycemia, as well as increased bleeding in patients with
hemophilia types A and B, have been reported with protease inhibitors.

    VIRACEPT(R) is a registered trademark of Agouron Pharmaceuticals, Inc.


                   CONSOLIDATED STATEMENT OF INCOME (LOSS)

                   (In thousands, except per share amounts)


                                  Three Months Ended          Year Ended
                                       June 30,                June 30,
                                    1998         1997      1998        1997
                                       (Unaudited)
    Revenues:
      Product sales             $126,046      $43,568  $409,298     $56,969
      Contracts                    7,782       16,259    38,855      65,094
      License fees and royalties   1,700        1,000    18,352      10,000
                                 135,528       60,827   466,505     132,063

    Operating expenses:
      Cost of product sales       51,409       18,576   172,644      24,599
      Research and development    61,544       26,770   150,657     108,137
      Selling, general and
        administrative            17,253       13,139    58,012      32,941
      Royalties                   21,534            0    68,423           0
      Write-off of in-process
        technology                     0       57,500         0      57,500
                                 151,740      115,985   449,736     223,177

    Operating income (loss)     (16,212)     (55,158)    16,769    (91,114)

    Other income (expense):
      Interest and other income    1,514          908     5,907       5,873
      Interest expense             (173)         (49)     (752)       (142)
                                   1,341          859     5,155       5,731

    Income (loss) before
      income taxes              (14,871)     (54,299)    21,924    (85,383)

    Income tax provision
      (benefit)                  (5,948)     (43,495)     8,770    (42,577)

    Net income (loss)           $(8,923)    $(10,804)   $13,154   $(42,806)

    Earnings (loss) per share:
      Basic                      $ (.29)       $(.38)     $ .43     $(1.59)
      Diluted                    $ (.29)       $(.38)     $ .40     $(1.59)

    Shares used in calculation of:
      Basic                       30,963       28,356    30,571      26,946
      Diluted                     30,963       28,356    33,214      26,946


                          CONSOLIDATED BALANCE SHEET

                           (Audited, in thousands)


                                                  June 30,        June 30,
                                                    1998             1997

    Assets:
      Cash, cash equivalents and short term
       investments                                 $87,123         $91,317
      Accounts receivable, net                      51,341          31,375
      Inventories                                  103,706          58,800
      Current deferred tax assets                      564             500
      Other current assets                           5,247           2,209
          Total current assets                     247,981         184,201

      Property and equipment, net                   47,212          22,613
      Deferred tax assets                           64,644          56,000
      Purchased intangibles                          3,500           4,100

                                                  $363,337        $266,914

    Liabilities and stockholders' equity:
      Accounts payable and accrued liabilities     $79,749         $37,722
      Deferred revenue and advances                 23,563          27,567
      Current deferred tax liabilities               1,139             600
      Loan payable and current portion
        of long-term debt                           15,802           2,526
          Total current liabilities                120,253          68,415

      Long-term debt, less current portion           5,892           5,940
      Accrued rent                                   1,023           1,277
      Stockholders' equity                         236,169         191,282

                                                  $363,337        $266,914

    Shares outstanding                              31,053          29,430



SOURCE Agouron Pharmaceuticals, Inc.




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    Head of Corporate Communications, 619-622-3009, or Media: Joy
    Schmitt, Associate Director, Product Public Relations,
    619-622-3220, both of Agouron Pharmaceuticals, Inc.