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Paradigm Genetics Announces 2003 Second Quarter Financial Results

                  Revenues up 27%, net loss reduced by 28%;
              Company accelerates focus on growth opportunities

    RESEARCH TRIANGLE PARK, N.C., Aug. 6 /PRNewswire-FirstCall/ -- Paradigm
Genetics, Inc. (Nasdaq: PDGM), a biotechnology company, today reported
financial results for the quarter ended June 30, 2003.  During the second
quarter, the company continued its positive trend by announcing increased
revenues over the first quarter and further reductions in its net loss and
improved cash flow from operations.
    Paradigm reported a second quarter 2003 net loss of $3.6 million, or $0.11
per common share, which is a 28% improvement over second quarter 2002 net loss
of $5.0 million, or $0.16 per common share.  The loss is in line with earlier
guidance provided by the company of $0.10 to $0.12 loss per common share.
    Total revenues for second quarter 2003 increased 27% to $5.6 million
compared to $4.4 million in the second quarter 2002.  This improvement was
primarily due to increases in revenues recognized from the new National
Institute of Environmental Health Sciences contract, a one-time service
contract and the Advanced Technology Program grant -- compared to no revenues
for these programs in the second quarter 2002.  These increases were partially
offset by anticipated decreases in revenues from Bayer CropSciences and The
Monsanto Company.  For the first six months of 2003, revenues decreased 4% to
$9.7 million compared to $10.1 million for the same period in 2002.  This
decrease was primarily due to anticipated decreases in revenues from Bayer
CropSciences and The Monsanto Company, partially offset by revenues from the
new NIEHS contract, a one-time service contract and the Advanced Technology
Program grant.
    While making targeted investments in its R&D programs for human health and
agriculture, Paradigm continued to reduce overall operating expenses.  Total
expenses for second quarter 2003 decreased 7% to $9.0 million compared to
$9.6 million in second quarter 2002.  For the first six months of 2003,
operating expenses decreased 16% to $17.0 million compared to $20.2 million
for the same period in 2002, due primarily to reduced payroll expenses and
other cost control measures.
    As further evidence of its improving financial health, the Company
reported:

    * Paradigm used approximately $1.7 million of cash in second quarter 2003
      compared to a use of $4.0 million in first quarter 2003 and $4.4 million
      in second quarter 2002.
    * Net cash used in operating activities decreased 81% to $0.6 million in
      second quarter 2003 compared to $2.9 million in first quarter 2003.
    * Capital expenditures in second quarter 2003 were held to $0.3 million.
      The company expects that the need for new capital expenditures will
      continue to remain at significantly lower levels than those experienced
      in prior years.
    * Debt payments in second quarter 2003 remained consistent with previous
      quarters at $1.1 million.  The $7.5 million refinancing with Silicon
      Valley Bank -- which closed in July 2003 and, therefore, is not included
      in second quarter 2003 results -- enabled Paradigm to pay off its
      approximately $3 million equipment loan with Transamerica Technology
      Finance, provided a $2.5 million revolving line of credit, and increased
      working capital by an additional $3.0 million.  The new financing is at
      substantially lower rates and will reduce scheduled debt payments by
      approximately $0.6 million for the remainder of the year.
    * While revenues were up $1.5 million, or 38%, to $5.6 million in second
      quarter 2003 from the first quarter 2003, total operating expenses only
      increased $0.9 million, or 11%, to $9.0 million for the same period.
      Further, approximately $0.5 million of the increase in expenses related
      to non-recurring charges.
    * As of June 30, 2003, the company reported unrestricted cash and
      investments in the amount of $15.5 million, in the form of cash, cash
      equivalents, short- and long-term investments, compared to $17.2 million
      at the end of the first quarter 2003.  On a pro forma basis, if the
      refinancing with Silicon Valley Bank had closed on June 30, 2003,
      unrestricted cash plus amounts available under the revolving line of
      credit would have totaled $19.6 million.  The company forecasts a year-
      end 2003 balance of unrestricted cash plus amounts available under the
      revolving line of credit of at least $13.0 to $15.0 million.

    "Our improved cash flow is direct evidence of the financial and
operational improvements we've made in the past 12 months.  Proactive
management of challenges such as delays in contract revenues or the Nasdaq
listing situation is now paying a dividend," said Heinrich Gugger, Ph.D.,
President and CEO of Paradigm Genetics.  "The recent refinancing with Silicon
Valley Bank, along with rigorous cash controls and operations improvements,
further solidifies our financial position and creates greater flexibility for
us.  Recent increases in work flow from the NIEHS contract and the opportunity
for increased revenues from our ATP grant help partially offset the normal
delays in closing new deals with large companies."
    "Looking forward," Gugger said, "we are focused on building on our core
competencies and providing results for our existing and future commercial
partners.  Additionally, to take Paradigm to the next level, we will leverage
our technology platforms to create a portfolio of proprietary products for our
human health business and novel product concepts for our agricultural
business.  By doing so, we can create the opportunity for long-term,
sustainable growth and a sustainable competitive advantage for Paradigm."

    About Paradigm Genetics
    Paradigm is a biotechnology company aiming to increase R&D productivity by
focusing its integrated suite of technologies on the product development
cycle, from target discovery to subsequent enhancement of the safety and
efficacy profiles of development candidates in agriculture and human health.
Paradigm chooses a systems biology approach to understand gene function in the
context of biological pathways, to develop assays and biomarkers for molecular
diagnostic solutions tailored to the needs of our partners.  Paradigm's
proprietary Gene to Cell to System(TM) approach has three major components:
gene expression profiling, biochemical profiling (also known as metabolomics)
and data integration and coherence.  For more information, visit
http://www.paradigmgenetics.com.

    Quarterly Conference Call
    Paradigm will host a conference call at 8:30 a.m. ET on Thursday,
August 7, 2003 to review financial results for the three months ended
June 30, 2003.  This call will be webcast via the Internet at
http://www.paradigmgenetics.com, where any supplemental financial information will be
available, and will be accessible through the investor relations section and
homepage of Paradigm's web site through August 21, 2003.  Contact Investor
Relations at (919) 425-3000 for information on accessing a taped replay via
telephone.

    Financial Charts Follow


                           PARADIGM GENETICS, INC.
                      CONDENSED STATEMENTS OF OPERATIONS
                                 (Unaudited)

                            Three Months Ended          Six Months Ended
                                 June 30,                    June 30,
                           2003          2002          2003         2002

    Revenues:
    Revenues from commercial
     and government
     contracts         $ 5,282,000   $ 4,414,000  $ 9,121,000  $ 10,057,000
    Grant revenues         315,000            --      543,000            --
    Total revenues       5,597,000     4,414,000    9,664,000    10,057,000

    Operating expenses:
     Research and development
    (includes $190,000 and
     $90,000 of stock based
     compensation expense for
     the three months ended
     June 30, 2003 and June 30,
     2002, respectively, and
     includes $326,000 and
     $195,000 of stock based
     compensation expense for
     the six months ended
     June 30, 2003 and June 30,
     2002,
     respectively;)      6,513,000     7,089,000   12,345,000    14,721,000

    Selling, general and
     administrative (includes
     $245,000 and $62,000 of
     stock based compensation
     expense for the
     three months ended
     June 30, 2003
     and June 30, 2002,
     respectively, and
     includes $394,000
     and $221,000 of
     stock based compensation
     expense for the six
     months ended June 30, 2003
     and June 30, 2002,
     respectively;)      2,446,000     2,506,000    4,698,000     5,451,000

    Total operating
     expenses            8,959,000     9,595,000   17,043,000    20,172,000

    Loss from
     operations         (3,362,000)   (5,181,000)  (7,379,000)  (10,115,000)

    Other interest
     income (expense),
     net                  (104,000)      (81,000)    (228,000)     (137,000)

    Net loss from continuing
     operations         (3,466,000)   (5,262,000)  (7,607,000)  (10,252,000)

    Discontinued
     operations           (121,000)      254,000      (96,000)       27,000

    Net loss attributable
     to common
     stockholders      $(3,587,000)  $(5,008,000) $(7,703,000) $(10,225,000)

    Net loss per share - basic and diluted
    Loss from continuing
     operations        $     (0.11)  $     (0.16) $     (0.24) $      (0.32)

    Loss from discontinued
     operations              (0.00)         0.01         0.00          0.00

    Net loss per
     common share      $     (0.11)  $     (0.16) $     (0.24) $      (0.32)

    Weighted average
     common shares
     outstanding - basic
     and diluted        32,068,000    31,942,000   32,054,000    31,940,000



                           Paradigm Genetics, Inc.
                         2003 Second-Quarter Results
                         Condensed Balance Sheet Data


                                                    June 30,   December 31,
                                                     2003          2002
                                                 (unaudited)

    Assets:
    Cash, cash equivalents, short-term
     investments                                $  9,318,000   $ 10,909,000
    Other current assets                           5,684,000      6,500,000
       Total Current Assets                       15,002,000     17,409,000
    Long term investments                          6,172,000     10,323,000
    Property plant & equipment net                19,840,000     22,431,000
    Other noncurrent assets                        1,707,000      2,459,000
    Total Assets                                $ 42,721,000   $ 52,622,000
    Liabilities and Stockholders' Equity:
    Current liabilities                         $ 17,358,000   $ 18,557,000
    Long-term obligations                          1,524,000      3,378,000
    Stockholders' equity                          23,839,000     30,687,000
    Total Liabilities and Stockholders' Equity  $ 42,721,000   $ 52,622,000


                           Paradigm Genetics, Inc.
 Supplemental Information Re:  Increase/(Decrease) in Cash, Cash Equivalents,
          Short - Term and Long - Term Investments (See Note Below)
                                 (Unaudited)

                           Three Months Ended            Six Months Ended
                                June 30                       June 30
                          2003           2002          2003           2002
    Net cash used in
     operating
     activities       $ (557,000)   $ (3,197,000)  $ (3,446,000) $ (9,471,000)

    Net cash (used in)
     provided by investing
     activities, excluding
     purchases and
     maturities of short-term
     and long-term
     investments        (122,000)         30,000       (139,000)     (646,000)

    Net cash used in
     financing
     activities       (1,053,000)     (1,245,000)    (2,157,000)   (4,872,000)

    Net decrease in cash,
     cash equivalents,
     short-term investments
     and long-term
     investments      (1,732,000)     (4,412,000)    (5,742,000)  (14,989,000)

    Cash, cash
     equivalents,
     short-term investments
     and long term
     investments,
     beginning of
     period           17,222,000      32,415,000     21,232,000    42,992,000

    Cash, cash
     equivalents,
     short-term investments
     and long term
     investments,
     end of period   $15,490,000     $28,003,000    $15,490,000   $28,003,000


    Note:  The above presentation of the change in cash and investments is not
meant to be in accordance with generally accepted accounting principles
("GAAP") in the U.S.  GAAP requires the presentation of a statement of cash
flows only (i.e., excluding changes in short and long-term investments).  In
order to fully assess the Company's liquidity position, management believes
that the cash flow measure presented above, which includes Short-Term and
Long-Term Investments, is an appropriate measure for evaluating the Company's
liquidity, because this reflects all liquid resources available for strategic
opportunities including, among others, to invest in the business and continue
operating activities.  However this measure should be considered in addition
to, and not as a substitute for, or superior to, cash flows, prepared in
accordance with generally accepted accounting principles in the U.S.
    Under GAAP, cash flows from investing activities above would improve by
net maturities of investment securities and unrealized gains and losses on
investments in the amount of $0.04 million and $5.7 million for the three
months ended June 30, 2003 and 2002, respectively, and by $6.1 million and
$13.3 million for the six months ended June 30, 2003 and 2002, respectively.
Also under GAAP, cash and cash equivalents at the beginning and end of the
period would be less, as they would exclude short and long-term investments of
$9.3 million and $29.3 million, and $9.3 million and $23.6 million for the
three months ended June 30, 2003 and 2002, respectively and by $15.3 million
and $36.8 million, and $9.3 million and $23.6 million for the six months ended
June 30, 2003 and 2002, respectively.  Cash, cash equivalents, short-term and
long-term investments exclude restricted cash.

    This press release contains forward-looking statements, including
statements regarding the Company's expectations regarding business development
activities and near-term revenue opportunities; the financial statement impact
of the significant reduction in SG&A expense and increase in R&D investment;
and the Company's ability to hit its milestones and execute on its strategy.
Such forward-looking statements are based on management's current expectations
and are subject to a number of risks, factors and uncertainties that may cause
actual results, events and performance to differ materially from those
referred to in the forward-looking statements.  These risks, factors and
uncertainties include, but are not limited to, Paradigm's early stage of
development, history of net losses, technological and product development
uncertainties, reliance on research collaborations, uncertainty of additional
funding and ability to protect its patents and proprietary rights.  Certain of
these and other risks are identified in Paradigm's annual report on Form 10-K
for the year ended December 31, 2002 and in its quarterly report on Form 10-Q
for the quarter ended March 31, 2003, each filed with the Securities and
Exchange Commission.  The Company does not intend to update any of the
forward-looking statements after the date of this release to conform these
statements to actual results or to changes in our expectations, except as may
be required by law.


SOURCE Paradigm Genetics, Inc.




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    CONTACT:
    Melissa Matson, Director, Corporate
    Communications of Paradigm Genetics, Inc., +1-919-425-3000, or
    Mark Vincent of Noonan Russo Presence Euro RSCG, +1-212-845-4200,
    for Paradigm Genetics, Inc.