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PDL Announces Senior Management Changes

    FREMONT, Calif., Sept. 15 /PRNewswire-FirstCall/ -- Protein Design Labs,
Inc. (PDL) (Nasdaq: PDLI) today announced the following senior management
changes:

    -- First, Mr. Glen Sato, Senior Vice President and Chief Financial Officer
       (CFO) is planning on resigning from PDL at year-end 2005 to join the
       life sciences practice of a leading law firm.  Effective November 2,
       2005, he will no longer be an officer of the company, though he will
       remain on staff as an employee until the end of year to ensure a smooth
       transition.  Starting November 2, Mr. George Jue, PDL's Vice President,
       Finance and Chief Accounting Officer, will oversee the financial
       organization of PDL and report directly to Mark McDade, PDL's Chief
       Executive Officer, until a new CFO is hired.  Mr. Jue previously served
       as Corporate Controller at Scios, Inc., a biopharmaceutical company
       affiliated with Johnson & Johnson.  Prior to Scios, he served in
       various financial management positions at Roche Bioscience, at
       Genentech, Inc. and at Lawrence Berkeley National Laboratories.  The
       company has initiated a search for a new CFO to meet the needs of its
       growing commercial enterprise.
    -- Second, PDL's Senior Vice President, Technical Operations, Mr. Brett
       Schmidli, will retire at the end of 2005.  He has served in this role
       since February 2002.  Prior to joining PDL, he held manufacturing and
       other positions at Eli Lilly and Genetics Institute.  Mr. Schmidli will
       continue to serve as a consultant during 2006 to provide additional
       guidance as the company continues to bring its new antibody
       manufacturing facilities operational during mid-2006.
    -- Third, Dr. Richard Murray has been promoted to the position of Senior
       Vice President, Chief Scientific and Technical Officer and he will now
       oversee all of the company's technical operations, including
       manufacturing.  He was previously PDL's Senior Vice President and Chief
       Scientific Officer.  Dr. Murray joined PDL's senior team as part of the
       company's acquisition of privately held Eos Biotechnology, where he was
       a co-founder and served as Vice President, Research.  Prior to Eos, he
       held several positions at DNAX Institute, a division of Schering
       Plough.
    -- Fourth, Mr. Eric Emery is being promoted to Vice President,
       Manufacturing from Vice President, Manufacturing Operations and will
       also serve as the Minnesota site head.  In his new role, he will report
       to Dr. Murray.  Mr. Emery has held several manufacturing positions at
       PDL since joining in 1996, and prior to that held additional
       manufacturing positions at Baxter.

    "These management changes are consistent with our maturing organization,"
said Mr. McDade.  "We thank Glen for his many contributions over the years in
several key areas, most importantly building a strong financial infrastructure
from which we can continue to grow.  We wish him the best as he pursues a
different career path in the life sciences industry.

    "We also appreciate Brett Schmidli's many accomplishments, including
overseeing the on-budget, on-time build-out of our new commercial-scale
antibody production facility in Brooklyn Park, and helping to build the
overall technical operations team from a small nucleus in Minnesota to a
significant multi-site and multi-disciplinary effort.  We are pleased he will
continue to help us in the coming year and wish him well in his future
endeavors," added Mr. McDade.  "At the same time, we are also pleased to
promote Dr. Richard Murray, who has successfully overseen much of the growth
and scale up of our research and process development, and Eric Emery, who will
step up to play a pivotal role in manufacturing, specifically at our Minnesota
site."
    PDL is a biopharmaceutical company focused on the research, development
and commercialization of novel therapies for inflammation and autoimmune
diseases, acute cardiac conditions and cancer. PDL markets several
biopharmaceutical products in the United States through its hospital sales
force and wholly-owned subsidiary, ESP Pharma, Inc. As a leader in the
development of humanized antibodies, PDL has licensed its patents to numerous
pharmaceutical and biotechnology companies, some of which are now paying
royalties on net sales of licensed products. Further information on PDL is
available at http://www.pdl.com.
    Protein Design Labs and the PDL logo are registered U.S. trademarks of
Protein Design Labs, Inc.


SOURCE Protein Design Labs, Inc.




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    CONTACT:
    James R. Goff, Senior Director, Investor
    Relations, of Protein Design Labs, Inc., +1-510-574-1421 or
    jgoff@pdl.com