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Vertex Pharmaceuticals Announces Webcast of its Presentation at the MASS Opportunities Biotechnology Investment Conference 2005

    CAMBRIDGE, Mass., Oct. 31 /PRNewswire-FirstCall/ -- Vertex Pharmaceuticals
Incorporated (Nasdaq: VRTX) will webcast its corporate presentation at the
MASS Opportunities Biotechnology Investment Conference 2005.  The MASS
Opportunities Conference is hosted by the Massachusetts Biotechnology Council
(MBC).  The presentation will be delivered by Lynne Brum, Vertex's Vice
President of Corporate Communications and Financial Planning on Thursday,
November 3, 2005 at 11:40 a.m. EST.
   The presentation will be webcast live and may be accessed by visiting the
Vertex website at http://www.vrtx.com.  A replay of the webcast will also be
available on the Company's website until November 14, 2005.  To access the
webcast, go to Vertex's website and select the 'MASS Opportunities:  A
Biotechnology Investment Conference' from the 'Events Calendar.'  To ensure a
timely connection to the webcast, it is recommended that users register at
least 15 minutes prior to the scheduled webcast.

    About Vertex
    Vertex Pharmaceuticals Incorporated is a global biotechnology company
committed to the discovery and development of breakthrough small molecule
drugs for serious diseases.  The Company's strategy is to commercialize its
products both independently and in collaboration with major pharmaceutical
companies.  Vertex's product pipeline is principally focused on viral
diseases, inflammation, autoimmune diseases and cancer.  Vertex co-promotes
the HIV protease inhibitor, Lexiva, with GlaxoSmithKline.

    Lexiva is a registered trademark of the GlaxoSmithKline group of
companies.

    Vertex's press releases are available at http://www.vrtx.com.

    Vertex Contact:
    Lora Pike, Manager, Investor Relations, (617) 444-6755


SOURCE Vertex Pharmaceuticals Incorporated




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    CONTACT:
    Lora Pike, Manager, Investor Relations of
    Vertex Pharmaceuticals Incorporated, +1-617-444-6755