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Applied Imaging Announces Collaboration With the Cleveland Clinic

    SANTA CLARA, Calif., Nov. 5 /PRNewswire/ -- Applied Imaging Corp. today
announced the formation of a clinical research imaging collaboration with the
Department of Anatomic Pathology at The Cleveland Clinic Foundation.
    As part of this collaboration, The Cleveland Clinic has purchased the
Company's Ariol(TM) automated image analysis system for use in its pathology
research programs. Investigators at The Cleveland Clinic have begun to utilize
the Ariol system in their ongoing research programs to more precisely
characterize gene and protein expression patterns in a wide range of cancers.
    Scientists at The Cleveland Clinic will also evaluate new applications
under development by Applied Imaging and provide input into the design of
novel imaging applications for the detection of extremely low levels of gene
amplification that may enhance the utility of other technologies already under
development at the Clinic.
    "Highly precise, quantitative measurement technologies are essential tools
to help us advance our understanding of the molecular and protein pathways
that are of clinical relevance in a number of cancers," said John Goldblum MD,
chairman, of Anatomic Pathology at The Cleveland Clinic. "These second-
generation systems developed by Applied Imaging have the capability to
substantially accelerate our research efforts in these areas. In addition, we
look forward to participating in the development and testing of a number of
new microscopic imaging applications with the Company's scientists."
    "We are very pleased to be working with The Cleveland Clinic in this
effort, given the Clinic's extensive experience with other microscopic imaging
technologies and the Clinic's commitment to the rapid incorporation of the
Ariol system into its research laboratory operations," commented Carl Hull,
Chief Executive Officer of Applied Imaging. "We believe that this
collaboration with one of the world's leading cancer treatment centers will
demonstrate both the clinical utility and research flexibility of the
pioneering applications that we have developed."

    About The Cleveland Clinic Foundation
    The Cleveland Clinic was founded in 1921 as a not-for-profit group
practice, integrating clinical and hospital care with research and physician
education. The Cleveland Clinic enjoys a strong reputation for outstanding
medical care. U.S News & World Report has declared that the Clinic is one of
the five "Best Hospitals in America."
    The surgical pathology service in the Division of Pathology and Laboratory
Medicine processes approximately 70,000 specimens annually, reflecting the
highly specialized medical and surgical practice of The Cleveland Clinic.

    About Applied Imaging
    Applied Imaging Corp., based in Santa Clara, California, is the leading
supplier of automated imaging systems utilized in genetics and pathology
laboratories throughout the world for the analysis of chromosomes in cancer
and prenatal disorders. The Company markets a range of imaging systems for
fluorescence and brightfield microscopy applications, including the Company's
Ariol(TM), MDS(TM), SPOT(TM), CytoVision(R), PowerGene(R) and QUIPS(R) product
lines. Applied Imaging has installed in excess of 3,000 systems in over 1,000
laboratories in more than 60 countries. Applied Imaging provides clinical and
research applications. A research application is not intended for in vitro
diagnostic or clinical use.

    This press release contains forward-looking statements as defined in the
Private Securities Litigation Reform Act of 1995, regarding, among other
matters, the timing and successful introduction of new and improved
microscopic imaging applications, as well as the duration and benefits of the
collaboration with The Cleveland Clinic. Forward looking statements address
matters that are subject to a number of risks, uncertainties and other
factors, detailed in the Company's periodic filings with the Securities and
Exchange Commission including, but not limited to, those risks and
uncertainties listed in the section entitled "Management's Discussion and
Analysis of Financial Condition and Results of Operations -- Factors Affecting
Future Results," in Applied Imaging's annual report on Form 10-K for the year
ended December 31, 2002. The forward-looking statements are made as of
November 5, 2003, and Applied Imaging is under no obligation to revise or
update the forward-looking statements.

    For additional information on Applied Imaging, visit the Company's Web
site at http://www.aicorp.com .


SOURCE Applied Imaging Corp.




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Related links:
  • http://www.aicorp.com
    CONTACT:
    Barry Hotchkies, CFO of Applied Imaging
    Corp., +1-408-562-0250; or Jocelyn Hunter of FRB/Weber Shandwick,
    +1-415-248-3433, for Applied Imaging Corp.