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Icoria Announces 2004 Third Quarter Financial Results

            -- Record Revenues - Up 19% Over Third Quarter 2003 --

    RESEARCH TRIANGLE PARK, N.C., Nov. 8 /PRNewswire-FirstCall/ -- Icoria,
Inc. (Nasdaq: ICOR), today reported financial results for the quarter ended
September 30, 2004.
    Icoria's strong performance under its existing contracts and growing
acceptance of its gene expression business led to its highest-ever quarterly
revenues.  For the third quarter of 2004, overall revenues increased by 19% to
$7.1 million as compared to $6.0 million in the third quarter of 2003.
Revenue for the nine months ended September 30, 2004 increased nearly 17% to
$18.3 million as compared to $15.7 million in the same period in 2003.
    "We are very pleased to report the highest ever quarterly revenue in
company history due primarily to increasing revenues earned on our existing
contracts with the National Institute of Environmental Health Sciences and
Pioneer, which offset the expected decline in revenues from our more mature
contracts with Monsanto and Bayer," said Heinrich Gugger, Ph.D.  "During the
third quarter, we also expanded the capabilities of our Paradigm Array Labs
("PAL") gene expression service business through the addition of laser capture
microdissection services, microRNA detection and analysis services and Good
Laboratory Practice ("GLP") compliance.  These new offerings have led to the
signing of new contracts with pharmaceutical companies, which we expect to
positively impact our PAL revenue during the fourth quarter of 2004."
    Dr. Gugger continued, "In addition, our healthcare team is continuing to
work on two customer pilot projects, one of which has entered into a second
phase, and we are hopeful that they will result in larger follow-on contracts.
We also continue to make meaningful progress with our Agriculture programs as
demonstrated by several new fungicide patents granted to Icoria during the
past year.  Finally, with the closing of our recently announced $5 million
convertible debt financing in October, we have extended our ability to
vigorously pursue our business opportunities by strengthening our liquidity
position."
    Total operating expenses for the third quarter 2004 increased to
$10.1 million, or by 26%, compared to $8.1 million in the third quarter 2003.
For the nine months ended September 30, 2004, total operating expenses
increased to $28.5 million, or by 13%, as compared to $25.1 million in the
same period in 2003.  These operating expenses reflect the second full quarter
of costs related to Icoria's acquisition of TissueInformatics.Inc on March 11,
2004.  The increases in operating costs for both the quarter and nine month
period ended September 30, 2004 were due primarily to materials costs
associated with higher revenues from the Company's contract with the National
Institute of Environmental Health Sciences, the evolution of its research and
development programs, additional sales and marketing costs associated with the
expansion of our offerings and amortization of intangible assets associated
with the TissueInformatics.Inc acquisition.
    Icoria reported a third quarter 2004 net loss of $3.1 million, or
$0.08 per common share, or 36% higher than the third quarter 2003 net loss of
$2.2 million, or $0.07 per common share.  For the nine months ended
September 30, 2004, Icoria reported a net loss of $10.3 million, or $0.29 per
common share, which is a 4% increase over the prior period net loss of
$9.9 million, or $0.31 per common share.
    As of September 30, 2004, the Company reported unrestricted cash, cash
equivalents and short-term investments in the amount of $7.1 million.
    During the third quarter of 2004, the Company reached an agreement with
General Electric Capital Corporation (GECC), which permitted the Company to
prepay without penalty the remaining note balance with GECC through payments
of $0.3 million in each of September and October 2004.  In addition, payments
from two customers totaling over $1 million, which were due and expected to be
received during the quarter, were delayed until the first week of October
2004.  Excluding the prepayment to GECC and the delay in customer receipts,
the net decrease in cash, cash equivalents and investments ("cash burn") for
the third quarter 2004 was $2.3 million, which consisted of $1.3 million from
operating activities, $0.5 million for capital expenditures and $0.5 million
for recurring term debt and capital lease obligations.  During the same period
in 2003 the comparable net cash burn was $2.2 million, excluding the impact of
new borrowings during that quarter.
    Icoria's Significant Third Quarter and Recent Accomplishments and
Activities:
    The Company has previously announced the following accomplishments and
activities (by release date), the full text of which may be found on our web
site at http://www.icoria.com/news :
    -- Icoria expands patent portfolio through the grant of its sixth
       fungicide target patent (October 26, 2004).
    -- Icoria raises $5 million gross proceeds through the sale of a three-
       year Secured Convertible Term Note in a private placement With Laurus
       Master Fund, Ltd. (October 21, 2004).
    -- Icoria signs an agreement with Rosetta Genomics, Ltd. to commercialize
       Rosetta Genomics' proprietary MirChip(TM) microRNA technology
       (October 18, 2004).
    -- Icoria expands partnering with Agilent Technologies to include
       $11.7 million ATP grant for Informatics (October 7, 2004).
    -- Icoria offers GLP compliant gene expression profiling services through
       its Paradigm Array Labs services unit (September 20, 2004).
    -- Icoria changes its corporate identity from Paradigm Genetics, Inc. to
       Icoria, Inc. to reflect its strategic transformation into a cutting-
       edge systems biology company (August 18, 2004).
    -- Icoria enters into collaboration with Arcturus Biosciences to provide
       microgenomics and laser capture microdissection technology services
       (August 12, 2004).

    About Icoria
    Icoria is an integrated systems biology company applying its proprietary
platform to the discovery and development of safer, more effective drugs and
agrichemicals.  Icoria has major contracts with the National Institute of
Environmental Health Sciences, Bayer CropScience, the Monsanto Company,
Pioneer Hi-Bred International (a subsidiary of DuPont) and L'Oreal Inc.
Icoria also has a major grant from the National Institute of Standards &
Technology's Advanced Technology Program.  For more information,
visit http://www.icoria.com .

    Quarterly Conference Call
    Icoria will host a conference call at 8:30 a.m. ET on Monday, November 8,
2004 to review financial results for the three months ended September 30,
2004. This call will be webcast via the Internet at http://www.icoria.com ,
where any supplemental financial information will be available, and will be
accessible through the investor relations section and home page of Icoria's
web site. To listen to the call via telephone, dial 800-500-0311 (U.S. and
Canadian callers) or 719-457-2698 (international callers) and enter conference
ID #820780. A replay of the webcast will be available via telephone from
11:00 a.m. on November 8, 2004 through midnight on November 12, 2004 at
888-203-1112 (U.S. and Canadian callers) or 719-457-0820 (international
callers) and enter conference ID #820780.  A replay of the webcast will also
be available via website until November 8, 2005.


                                 ICORIA, INC.
                      CONDENSED STATEMENTS OF OPERATIONS
                                 (Unaudited)

                             Three Months Ended       Nine Months Ended
                                September 30,            September 30,
                              2004        2003         2004         2003
    Revenues:
    Revenues from
     commercial and
     government contracts  $6,798,000   $5,135,000   $17,073,000  $14,256,000
    Grant revenues            322,000      867,000     1,189,000    1,410,000
    Total revenues          7,120,000    6,002,000    18,262,000   15,666,000

    Operating expenses:
    Research and
     development            7,524,000    6,172,000    20,555,000   18,516,000
    Selling, general and
     administrative         2,610,000    1,882,000     7,909,000    6,580,000

    Total operating
     expenses              10,134,000    8,054,000    28,464,000   25,096,000

    Loss from operations   (3,014,000)  (2,052,000)  (10,202,000)  (9,430,000)

    Other interest
     income (expense), net    (46,000)    (228,000)     (173,000)    (456,000)

    Net loss from
     continuing operations (3,060,000)  (2,280,000)  (10,375,000)  (9,886,000)

    Discontinued operations     6,000       37,000        32,000      (60,000)

    Net loss attributable
     to common
     stockholders         $(3,054,000) $(2,243,000) $(10,343,000) $(9,946,000)

    Net loss per share -
     basic and diluted
     Loss from continuing
     operations                $(0.08)      $(0.07)      $ (0.29)     $ (0.31)

    Loss from discontinued
     operations                  0.00         0.00          0.00         0.00

    Net loss per common share  $(0.08)     $ (0.07)      $ (0.29)     $ (0.31)

    Weighted average
     common shares
     outstanding -
     basic and diluted     36,300,000   32,564,000    35,325,000   32,226,000


                                 Icoria, Inc.
                          2004 Third-Quarter Results
                         Condensed Balance Sheet Data

                                                  September 30,   December 31,
                                                      2004            2003
                                                   (unaudited)

    Assets:
    Cash, cash equivalents, short-term investments   $7,087,000    $16,285,000
    Other current assets                              4,029,000      4,005,000
        Total Current Assets                         11,116,000     20,290,000
    Property plant & equipment net                   15,638,000     17,337,000
    Other noncurrent assets                           5,068,000      1,827,000
    Total Assets                                    $31,822,000    $39,454,000
    Liabilities and Stockholders' Equity:
    Current liabilities                              14,101,000     16,094,000
    Long-term obligations                             3,689,000      3,846,000
    Stockholders' equity                             14,032,000     19,514,000
    Total Liabilities and Stockholders' Equity      $31,822,000    $39,454,000


                                 Icoria, Inc.
 Supplemental Information Re: Increase/(Decrease) in Cash, Cash Equivalents,
          Short - Term and Long - Term Investments (See Note Below)
                                 (Unaudited)

                              Three Months Ended         Nine Months Ended
                                  September 30              September 30
                               2004         2003         2004         2003
    Net cash used in
     operating activities  $(2,277,000) $(2,059,000) $(6,001,000) $(5,505,000)

    Net cash (used in)
     provided by investing
     activities, excluding
     purchases and maturities
     of short-term and
     long-term investments    (527,000)    (103,000)   1,294,000     (242,000)

    Net cash (used in) provided
     by financing activities  (832,000)   2,701,000   (4,491,000)     544,000

    Net decrease in cash, cash
     equivalents, short-term
     investments and long-
     term investments       (3,636,000)     539,000   (9,198,000)  (5,203,000)

    Cash, cash equivalents,
     short-term investments
     and long term investments,
     beginning of period    10,723,000   15,490,000   16,285,000   21,232,000

    Cash, cash equivalents,
     short-term investments
     and long term investments,
     end of period          $7,087,000  $16,029,000   $7,087,000  $16,029,000


    Note: The above presentation of the change in cash and investments is not
meant to be in accordance with generally accepted accounting principles
("GAAP") in the U.S.  GAAP requires the presentation of a statement of cash
flows only (i.e., excluding changes in short and long-term investments). In
order to fully assess the Company's liquidity position, management believes
that the cash flow measure presented above, which includes short-term
investments, is an appropriate measure for evaluating the Company's liquidity,
because this reflects all liquid resources available for strategic
opportunities including, among others, to invest in the business and continue
operating activities. However this measure should be considered in addition
to, and not as a substitute for, or superior to, cash flows prepared in
accordance with generally accepted accounting principles in the U.S.
    Under GAAP, cash flows from investing activities above would improve by
net maturities of investment securities in the amount of $3.0 million and
$0.05 million for the three months ended September 30, 2004 and 2003,
respectively, and by $6.1 million and $6.2 million for the nine months ended
September 30, 2004 and 2003, respectively. Also under GAAP, cash and cash
equivalents at the beginning and end of the period would be less, as they
would exclude investments of $6.0 million and $3.0 million, and $9.2 million
and $9.2 million for the three months ended September 30, 2004 and 2003,
respectively and by $9.1 million and $3.0 million, and $15.3 million and
$9.2 million for the nine months ended September 30, 2004 and 2003,
respectively. Cash, cash equivalents, short-term and long-term investments
exclude restricted cash.
    This press release contains forward-looking statements, including
statements regarding the Company's expectations for using its systems biology
platform to discover biomarkers and inaccessible targets for small molecule
discovery. Such forward-looking statements are based on management's current
expectations and are subject to a number of risks, factors and uncertainties
that may cause actual results, events and performance to differ materially
from those referred to in the forward-looking statements. These risks, factors
and uncertainties include, but are not limited to, Icoria's early stage of
development, history of net losses, technological and product development
uncertainties, reliance on research collaborations, uncertainty of additional
funding and ability to protect its patents and proprietary rights. Certain of
these and other risks are identified in Icoria's annual report on Form 10-K
for the year ended December 31, 2003 and in its quarterly report on Form 10-Q
for the quarter ended June 30, 2004, each filed with the Securities and
Exchange Commission. The Company does not intend to update any of the forward-
looking statements after the date of this release to conform these statements
to actual results or to changes in our expectations, except as may be required
by law.


SOURCE Icoria, Inc.




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