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Trega Biosciences Reports Third-Quarter 2000 Results

               - Third Quarter Highlighted by iDEA (TM) License
                       to Johnson & Johnson Companies -

    SAN DIEGO, Nov. 9 /PRNewswire/ -- Trega Biosciences, Inc. (Nasdaq: TRGA),
focused on commercializing technologies and products for accelerating drug
discovery and development, today announced financial results for the third
quarter ended September 30, 2000.  Revenues for the third quarter were
$3.4 million, compared with revenues of $2.0 million for the previous quarter.
Revenues for the third quarter 1999 were $4.0 million, which included one-time
payments from members of the consortium of companies with whom Trega
collaborated for the development of the initial version of the iDEA (TM)
Predictive ADME Simulation System for absorption.  Revenues from the sale of
chemical compounds for the third quarter were $2.5 million, compared with
$2.8 million in the third quarter of 1999.
    The net loss for the third quarter of 2000 was $4.1 million, or $0.18 per
share, compared with a net loss of $2.3 million, or $0.13 per share, in the
comparable period in 1999.  Expenses for the quarter increased approximately
$1.0 million over the prior year due primarily to transactions related to the
manufacture of compounds for a single customer and software licenses purchased
to support the enterprise version of Trega's iDEA (TM) Predictive ADME
Simulation System.  These expenses are not expected to continue in future
quarters.
    Revenues for the nine months ended September 30, 2000 were $8.0 million
compared with revenues of  $8.8 million for the same period last year.  The
net loss for the nine months was $11.6 million, or $0.53 per share, compared
with $8.5 million, or $0.47 per share, for the nine months ended September 30,
1999.  Trega ended the third quarter of 2000 with approximately $5.8 million
in cash, cash equivalents and short-term investments.  Additionally, current
assets at the end of the quarter included approximately $3.0 million in
accounts receivable.
    "In line with our strategy, Trega has in recent months advanced the
development and commercialization of its iDEA (TM) Predictive ADME Simulation
System, which simulates, in silico, how drug candidates will be processed in
the body.  We are excited to see that the trend toward in silico testing is
gathering momentum among research scientists, as evidenced by a number of
presentations last week at the American Association of Pharmaceutical
Scientists conference.  These included several presentations on our iDEA (TM)
module for absorption, which is the only absorption model commercially
available with an independently validated high level predictive capability.
We also previewed at the meeting our iDEA (TM) module for metabolism, which is
scheduled for a year-end commercial launch," said Michael G. Grey, President
and CEO of Trega Biosciences.
    Mr. Grey continued, "During the third quarter, we completed initial
license agreements to the iDEA (TM) absorption module with F. Hoffmann-
LaRoche, Ltd. and Aventis Pharma AG as well as a worldwide license for both
the absorption and metabolism modules to Janssen Research Foundation and its
Johnson & Johnson affiliates.  Revenues from the iDEA (TM) licenses will be
recognized over the term of the licenses.  Moreover, in this quarter we
continued to provide Chem.Folio (R) combinatorial libraries to both new and
repeat customers."
    Trega Biosciences, Inc. is a premier provider of products that accelerate
and improve drug discovery through its iDiscovery (TM) technologies linking
biology and chemistry with information technologies.  Trega's iDEA (TM)
Predictive ADME Simulation System of information-based models simulate, in
silico, how drug candidates will be processed in the body, thereby enabling
selection of those with optimal characteristics for clinical development.
Together with its iDEA (TM) products, Trega's Chem.Folio (R) libraries of
information-enhanced small molecules are designed to facilitate the
identification and optimization of drug candidates.  For additional
information on Trega, please visit our Web site at http://www.trega.com.

    Except for the historical information contained herein, the matters
discussed in this news release are forward-looking statements that involve
risks and uncertainties.  The Company's quarterly and annual financial
performance may be subject to fluctuations depending on factors such as the
receipt, timing and amount of revenue recognized from sales, licenses and
collaborations, timing of the delivery of products and technologies, the
completion of contracted service commitments to Trega's customers and
partners, and potential future acquisitions or disposition of complementary
assets or technologies.  Accordingly, revenue and operating results for prior
periods may not be indicative of Trega's future financial results.  Other
forward-looking statements could include whether the Company's resources are
sufficient to enable it to reach its business objectives, whether any research
or development activities to be conducted as described will be successful,
whether any additional collaborations or alliances will be formed or expanded,
whether any such products can be successfully marketed, the impact of
competitive products and pricing in marketing success, whether any other
corporate collaborations or alliances will be successful, and other risks
detailed from time to time in Trega's Securities and Exchange Commission
filings.  These forward-looking statements represent Trega's judgment as of
the date of this release. Actual results may differ materially from those
projected.  Trega disclaims, however, any intent or obligation to update these
forward-looking statements.


                           TREGA BIOSCIENCES, INC.
               Condensed Consolidated Statements of Operations
                                 (Unaudited)
                    (in thousands, except per share data)


                              Three Months Ended         Nine Months Ended
                                September 30,               September 30,
                              2000         1999          2000         1999


    Revenues:
     Compound revenues      $2,504        $2,822       $4,814        $4,383
     Contract research
      and licenses fees        899         1,102        3,183         4,133
     Net sales                   7            76           50           265

    Total revenues           3,410         4,000        8,047         8,781

    Costs and expenses:
     Cost of sales              29            83          136           242
     Research and
      development            5,036         4,593       13,635        13,534
     Selling, general
      and administrative     2,271         1,682        6,568         5,187

    Total costs
     and expenses            7,336         6,358       20,339        18,963

    Loss from operations
     before equity in losses
     of affiliate         $(3,926)      $(2,358)    $(12,292)     $(10,182)

    Equity in losses
     of affiliate            (111)          (16)        (451)          (16)

    Loss from operations   (4,037)       (2,374)     (12,743)      (10,198)

    Interest and
     other income
     (expense), net           (78)            32        1,180         1,687

    Net loss              $(4,115)      $(2,342)    $(11,563)      $(8,511)

    Basic and diluted
     net loss per share    $(0.18)       $(0.13)      $(0.53)       $(0.47)

    Shares used in
     computing basic
     and diluted
     net loss per share     23,337        18,537       21,986        18,150


                           TREGA BIOSCIENCES, INC.
                    Condensed Consolidated Balance Sheets
                                (in thousands)

                                                 September 30,  December 31,
                                                      2000          1999
                                                   (unaudited)

    Cash, cash equivalents and
     short-term investments                           $5,840         $6,434
    Accounts receivable and
     other current assets                              3,888          2,541
    Property and equipment, net                        4,647          4,179
    Other assets                                       8,460          9,507
     Total assets                                    $22,835        $22,661

    Current liabilities                               $7,866         $8,155
    Long-term liabilities                              3,510          2,996
    Stockholders' equity                              11,459         11,510
     Total liabilities and stockholders' equity      $22,835        $22,661


    CONTACTS:
     Gerard A. Wills
     Chief Financial Officer
     858-410-6695

     Cynthia Reindal
     Associate, Corporate Communications
     & Investor Relations
     858-410-6601


SOURCE Trega Biosciences, Inc.




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  • http://www.trega.com
    Company News On-Call:
  • http://www.prnewswire.com/comp/374050.html or fax,
    800-758-5804, ext. 374050
    CONTACT:
    Gerard A. Wills, Chief Financial Officer,
    858-410-6695, or Cynthia Reindal, Associate, Corporate
    Communications & Investor Relations, 858-410-6601 both of Trega
    Biosciences, Inc.