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Trega Biosciences Reports Third-Quarter 1998 Results

    SAN DIEGO, Nov. 11 /PRNewswire/ -- Trega Biosciences, Inc. (Nasdaq: TRGA)
today reported financial results for the third quarter and the nine-month
period ended September 30, 1998.  Revenues for the third quarter increased to
$2.0 million, compared with revenues of $1.4 million in the same period for
1997.  The net loss for the third quarter of 1998 was $3.7 million, or
$0.26 per share, compared with a net loss of $3.5 million, or $0.25 per share,
in the comparable period in 1997.  For the nine months ended September 30,
1998, total revenues increased to $7.2 million, compared with $5.4 million for
same period last year.  The net loss for the nine months was $9.5 million, or
$0.68 per share, compared with $7.0 million, or $0.52 per share, for the nine
months ended September 30, 1997.
    Trega ended the quarter with approximately $10.5 million in cash, cash
equivalents and short-term investments, which does not included $7.0 million
in proceeds that the Company received in November from the sale of common
stock at $3.75 per share to Novartis Pharma AG.
    "It has been an important third quarter," said Robert S. Whitehead,
chairman and chief executive officer.  "We reached critical milestones in our
agreement with Ono Pharmaceuticals, we continued to make progress on the
clinical study of HP 228 and we had two important broad drug discovery patents
issued to our ChromaXome subsidiary.  Most recently, we completed the first of
our Chem.Folio partnerships with Biogen and announced the receipt of
$7 million from Novartis, our metabolic diseases partner in exchange for
approximately 1.9 million shares of Trega stock."
    Increased revenues in the third quarter and nine month period ended
resulted primarily from collaborative agreements related to the company's
combinatorial libraries and research conducted under new and existing
collaborative agreements.  Research and development expenses increased to
$4.7 million in the third quarter of 1998, compared with $4.0 million in the
same quarter last year.  The increase in expenses was due to increased funding
of the Company's external drug discovery programs and the Company's
combinatorial chemistry, automation and robotics synthesis programs.  Selling,
general and administrative expenses of $1.2 million remained unchanged from
the comparable period last year.  For the nine months ended September 30,
1998, research and development expenses increased to $13.5 million, compared
with $10.5 million for the same period last year.  Selling, general and
administrative expenses decreased to $3.6 from $3.8 million in the comparable
period last year.
    Trega Biosciences is a drug discovery company utilizing combinatorial
chemistry and other technologies to pursue the discovery of novel, small
molecule drug therapies.  The Company leverages its technology platform by
entering into pharmaceutical alliances, which provide partners with access to
Trega's technologies in exchange for licensing fees and potential milestones
and royalties, or by establishing joint-discovery alliances with
pharmaceutical and biotechnology companies.  Trega also uses its drug
discovery technologies in its internal development programs, which are focused
today on discovering small molecules acting on melanocortin receptors.
Melanocortins are a class of receptors which may be important in the treatment
of inflammatory and metabolic diseases.

    Except for the historical information contained herein, the matters
discussed in this news release are forward-looking statements that involve
risks and uncertainties, including whether the Company's resources are
sufficient to enable it to reach its business objectives, any research to be
conducted as described will be successful, any additional collaborations or
alliances will be agreed to, formed or expanded, whether regulatory approvals
can be obtained for products discovered and developed, if any, whether any
such products can be successfully marketed, the impact of competitive products
and pricing, in marketing success, whether any other corporate collaborations
or alliances will be successful, and other risks detailed from time to time in
Trega's Securities and Exchange Commission filings.  These forward-looking
statements represent Trega's judgment as of the date of this release.  Actual
results may differ materially from those projected.  Trega disclaims, however,
any intent or obligation to update these forward-looking statements.

    Trega's releases are on the World Wide Web at http://www.trega.com and PR
Newswire's fax-on-demand service at 1-800-758-5804, extension 374050.

                             TREGA BIOSCIENCES, INC.
                      Condensed Consolidated Balance Sheets
                      (in thousands, except per share data)

                                September 30,           December 31,
                                     1998                    1997
    ASSETS                       (unaudited)
     Current assets:
      Cash, cash equivalents
       and short-term
        investments               $10,535                 $19,427
      Accounts receivable
       and other current assets     1,407                     676
    Total current assets           11,942                  20,103

    Property and equipment, net     4,292                   2,741
    Other assets                    2,032                   2,275
    Total assets                  $18,266                 $25,119

    LIABILITIES AND STOCKHOLDERS' EQUITY
     Current liabilities:
      Accounts payable             $1,981                    $211
      Accrued liabilities           1,523                   1,976
      Current portion of debt
       obligations                  1,005                   2,123
      Deferred revenue              4,050                   3,002
    Total current liabilities       8,559                   7,312
    Obligations under capital
     leases                           144                     298
    Long-term equipment notes
     payable                        1,942                   1,159
    Long-term notes payable            34                     132
    Deferred rent                     139                      --
    Total liabilities              10,818                   8,901

    Stockholders' equity:
     Common stock                      14                      14
     Additional paid-in capital    73,327                  73,087
     Common stock issuable             16                      16
     Deferred compensation,
      net                           (774)                 (1,270)
     Accumulated deficit         (65,135)                (55,629)
    Total stockholders' equity      7,448                  16,218
    Total liabilities and
     stockholders' equity         $18,266                 $25,119

                             TREGA BIOSCIENCES, INC.
                 Condensed Consolidated Statements of Operations
                                   (Unaudited)
                      (in thousands, except per share data)

                              Three Months Ended         Nine Months Ended
                                 September 30,             September 30,
                             1998          1997          1998          1997

    Revenues:
      Contract research
       and licenses fees    $2,043        $1,437       $7,217        $4,951
      Net sales                 --            --           --           430

    Total revenues           2,043         1,437        7,217         5,381

    Operating expenses:
      Cost of sales             --            --           --           341
      Research and
       development           4,658         3,963       13,533        10,471
      Selling, general
       and administrative    1,227         1,238        3,619         3,807

    Total operating expenses 5,885         5,201       17,152        14,619

    Loss from operations    (3,842)      $(3,764)     $(9,935)      $(9,238)

    Interest and other
     income/(expense), net     142           312          429         2,217

    Net loss               $(3,700)      $(3,452)     $(9,506)      $(7,021)

    Basic and Diluted
     Net loss per share     $(0.26)      $(0.25)       $(0.68)       $(0.52)

    Shares used in
     computing basic
     and diluted net
     loss per share         13,982        13,685       13,948        13,522


SOURCE Trega Biosciences, Inc.




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    CONTACT:
    Vince Reardon, Director, Corporate
    Communications of Trega Biosciences, Inc., 619-410-6555