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Paradigm Genetics Announces 2003 Third Quarter Financial Results

              Revenues Increased by 15%; Net Loss Reduced by 43%

    RESEARCH TRIANGLE PARK, N.C., Nov. 12 /PRNewswire-FirstCall/ -- Paradigm
Genetics, Inc. (Nasdaq: PDGM), a biotechnology company, today reported
financial results for the quarter ended September 30, 2003. During the third
quarter, the company significantly reduced its net loss, while increasing
revenues.
    Paradigm Genetics reported a third quarter 2003 net loss of $2.2 million,
or $0.07 per common share, which is a 43% improvement over the third quarter
2002 net loss of $3.9 million, or $0.12 per common share. The loss is in line
with earlier guidance provided by the company of $0.06 to $0.07 loss per
common share.
    Total revenues for third quarter 2003 increased 15% to $6.0 million
compared to $5.2 million in the third quarter 2002. For the first nine months
of 2003, revenues increased 3% to $15.7 million compared to $15.3 million for
the same period in 2002. These improvements were primarily due to increases in
revenues recognized from the National Institute of Environmental Health
Sciences (NIEHS) contract and the Advanced Technology Program (ATP) grant,
partially offset by anticipated decreases in revenues from Bayer CropScience
and The Monsanto Company and other previously completed commercial agreements.
Revenues from sources other than the Bayer and Monsanto contracts have grown
during each of the past two quarters by an average of 68% and are expected to
continue to grow.
    Total expenses for third quarter 2003 decreased 6% to $8.1 million
compared to $8.6 million in third quarter 2002. For the first nine months of
2003, operating expenses decreased 13% to $25.1 million compared to $28.8
million for the same period in 2002, due primarily to the company's internal
reorganization in April 2002 as well as continued cost controls. The company
indicated that cost savings from productivity gains have been partially
reinvested into further developing its human health offering.
    As of September 30, 2003, the company reported unrestricted cash and
investments in the amount of $16.0 million, in the form of cash, cash
equivalents, short- and long-term investments, compared to $15.5 million at
the end of second quarter 2003. The company's improved cash balance was due to
net proceeds from its recent financing with Silicon Valley Bank and temporary
borrowing on September 30, 2003 in the amount of $1.5 million, which was
repaid in October, partially offset by the use of cash in operations.
    "Paradigm has delivered strong operational improvement during the last
several quarters. Our repositioned core programs as well as our strengthened
balance sheet, helped by the restructuring of our existing debt, provide a
firm foundation for Paradigm's future growth," said Heinrich Gugger, Ph.D.,
President and CEO of Paradigm Genetics. "We expect an expansion of our
microarray services business (Paradigm Array Labs(TM)), enhanced by our recent
agreements with Affymetrix and Agilent, to contribute incremental revenue in
the near term. In parallel, we continue to seek revenue generating research
collaborations and other sources of funding to accelerate the building of an
internal product portfolio based on proprietary biomarkers and drug targets."

    About Paradigm Genetics
    Paradigm is a biotechnology company driving R&D productivity by focusing
its integrated suite of technologies on the product development cycle - from
target discovery to the subsequent enhancement of the safety and efficacy
profiles of development candidates in agriculture and human health. Paradigm
chooses a systems biology approach to understand gene function in the context
of biological pathways, and to develop assays and biomarkers for molecular
diagnostic solutions tailored to the needs of our partners. Paradigm's
proprietary Gene to Cell to System(TM) approach has four major components:
gene expression profiling, biochemical profiling (also known as metabolomics),
phenotypic profiling and data integration and coherence. For more information,
visit http://www.paradigmgenetics.com.

    Quarterly Conference Call
    Paradigm will host a conference call at 8:30 a.m. ET on Thursday, Nov. 13,
2003 to review financial results for the three months ended September 30,
2003. This call will be webcast via the Internet at http://www.paradigmgenetics.com,
where any supplemental financial information will be available, and will be
accessible through the investor relations section and homepage of Paradigm's
web site. To listen to the call via telephone, dial 800-289-0493 (U.S. and
Canadian callers) or 913-981-5520 (international callers) and enter conference
ID #602856. A taped replay will be available at the same number from 11:30
a.m. on Nov. 13 through midnight on Nov. 17.



                           PARADIGM GENETICS, INC.
                      CONDENSED STATEMENTS OF OPERATIONS
                                 (Unaudited)

                            Three Months Ended      Nine Months Ended
                               September 30,           September 30,
                              2003        2002        2003        2002

    Revenues:
    Revenues from commercial
     and government
     contracts            $5,135,000   $5,135,000  $14,256,000  $15,192,000
    Grant revenues           867,000       75,000    1,410,000       75,000
    Total revenues         6,002,000    5,210,000   15,666,000   15,267,000

    Operating expenses:
    Research and development
    (includes $53,000 and
    $78,000 of stock based
    compensation expense
    for the three months
    ended September 30, 2003
    and 2002, respectively,
    and includes $378,000
    and $272,000 of stock based
    compensation expense for
    the nine months ended
    September 30, 2003 and
    2002, respectively)    6,172,000    5,992,000   18,516,000   20,713,000

    Selling, general and
     administrative (includes
     $40,000 and $50,000 of
     stock based compensation
     expense for the three months
     ended September 30, 2003
     and 2002, respectively, and
     includes $434,000 and
     $272,000 of stock based
     compensation expense for
     the nine months ended
     September 30, 2003 and
     2002, respectively)   1,882,000    2,606,000    6,580,000    8,057,000

    Total operating
     expenses              8,054,000    8,598,000   25,096,000   28,770,000

    Loss from operations  (2,052,000)  (3,388,000)  (9,430,000) (13,503,000)

    Other interest income
     (expense), net         (228,000)     (79,000)    (456,000)    (216,000)

    Net loss from continuing
     operations           (2,280,000)  (3,467,000)  (9,886,000) (13,719,000)

    Discontinued operations   37,000     (466,000)     (60,000)    (439,000)

    Net loss attributable to
     common stockholders $(2,243,000) $(3,933,000) $(9,946,000)$(14,158,000)

    Net loss per share
     - basic and diluted
    Loss from continuing
     operations               $(0.07)      $(0.12)      $(0.31)      $(0.43)

    Loss from discontinued
     operations                (0.00)        0.00         0.00        (0.01)

    Net loss per common share$ (0.07)     $ (0.12)     $ (0.31)     $ (0.44)

    Weighted average common
     shares outstanding
     - basic and diluted  32,564,000   31,994,000   32,226,000   31,958,000



                           Paradigm Genetics, Inc.
                          2003 Third Quarter Results
                         Condensed Balance Sheet Data

                                                September 30,  December 31,
                                                    2003          2002
                                                 (unaudited)

    Assets:
    Cash, cash equivalents, short-term
     investments                                  $9,912,000    $10,909,000
    Other current assets                           5,457,000      6,500,000
    Total Current Assets                          15,369,000     17,409,000
    Long term investments                          6,117,000     10,323,000
    Property plant & equipment net                18,521,000     22,431,000
    Other noncurrent assets                        1,759,000      2,459,000
    Total Assets                                 $41,766,000    $52,622,000
    Liabilities and Stockholders' Equity:
    Current liabilities                           15,814,000     18,557,000
    Long-term obligations                          4,296,000      3,378,000
    Stockholders' equity                          21,656,000     30,687,000
    Total Liabilities and Stockholders' Equity   $41,766,000    $52,622,000



                           Paradigm Genetics, Inc.
  Supplemental Information Re:Increase/(Decrease) in Cash, Cash Equivalents,
          Short - Term and Long - Term Investments (See Note Below)
                                 (Unaudited)

                              Three Months Ended      Nine Months Ended
                                 September 30            September 30

                                2003       2002         2003        2002
    Net cash used in
     operating activities $(2,059,000) $(3,335,000)$(5,505,000)$(12,806,000)

    Net cash (used in)
     provided by investing
     activities, excluding
     purchases and maturities
     of short-term and
     long-term investments   (103,000)     115,000    (242,000)   (531,000)

    Net cash provided by
     (used in) financing
     activities             2,701,000   (1,323,000)    544,000  (6,195,000)

    Net increase (decrease)
     in cash, cash equivalents,
     short-term investments
     and long-term
     investments              539,000   (4,543,000) (5,203,000)(19,532,000)

    Cash, cash equivalents,
     short-term investments
     and long term investments,
     beginning of period   15,490,000   28,003,000  21,232,000  42,992,000
    Cash, cash equivalents,
     short-term investments
     and long term investments,
     end of period        $16,029,000  $23,460,000 $16,029,000 $23,460,000


    Note: The above presentation of the change in cash and investments is not
meant to be in accordance with generally accepted accounting principles
("GAAP") in the U.S.  GAAP requires the presentation of a statement of cash
flows only (i.e., excluding changes in short and long-term investments). In
order to fully assess the Company's liquidity position, management believes
that the cash flow measure presented above, which includes Short-Term and
Long-Term Investments, is an appropriate measure for evaluating the Company's
liquidity, because this reflects all liquid resources available for strategic
opportunities including, among others, to invest in the business and continue
operating activities. However this measure should be considered in addition
to, and not as a substitute for, or superior to, cash flows, prepared in
accordance with generally accepted accounting principles in the U.S.
    Under GAAP, cash flows from investing activities above would improve by
net maturities of investment securities and unrealized gains and losses on
investments in the amount of $0.05 million and $4.4 million for the three
months ended September 30, 2003 and 2002, respectively, and by $6.2 million
and $17.7 million for the nine months ended September 30, 2003 and 2002,
respectively. Also under GAAP, cash and cash equivalents at the beginning and
end of the period would be less, as they would exclude short and long-term
investments of $9.2 million and $9.2 million, and $23.6 million and $19.2
million for the three months ended September 30, 2003 and 2002, respectively
and by $15.3 million and $9.2 million, and $36.8 million and $19.2 million for
the nine months ended September 30, 2003 and 2002, respectively. Cash, cash
equivalents, short-term and long-term investments exclude restricted cash.

    This press release contains forward-looking statements, including
statements regarding the Company's expectations regarding business development
activities and near-term revenue opportunities; the financial statement impact
of the significant reduction in SG&A expense and increase in R&D investment;
and the Company's ability to hit its milestones and execute on its strategy.
Such forward-looking statements are based on management's current expectations
and are subject to a number of risks, factors and uncertainties that may cause
actual results, events and performance to differ materially from those
referred to in the forward-looking statements. These risks, factors and
uncertainties include, but are not limited to, Paradigm's early stage of
development, history of net losses, technological and product development
uncertainties, reliance on research collaborations, uncertainty of additional
funding and ability to protect its patents and proprietary rights. Certain of
these and other risks are identified in Paradigm's annual report on Form 10-K
for the year ended December 31, 2002 and in its quarterly report on Form 10-Q
for the quarter ended June 30, 2003, each filed with the Securities and
Exchange Commission. The Company does not intend to update any of the forward-
looking statements after the date of this release to conform these statements
to actual results or to changes in our expectations, except as may be required
by law.


SOURCE Paradigm Genetics, Inc.




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    CONTACT:
    Melissa Matson, Director, Corporate
    Communications, of Paradigm Genetics, Inc., +1-919-425-3000, or
    Brian Ritchie or Mark Vincent of Noonan Russo Presence Euro RSCG,
    +1-212-845-4200