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Signet Laboratories Announces Availability of Polyclonal Hepsin

 Leading medical diagnostics/research company releases new research-use-only
               polyclonal antibody for prostate cancer research

    DEDHAM, Mass., Nov. 17 /PRNewswire/ -- Signet Laboratories, Inc., a
leading medical diagnostics/research company specializing in the development
of monoclonal antibodies and diagnostic assays for cancer, infectious disease,
and neurodegenerative disease, today announced the availability of polyclonal
Hepsin antibody.
    Hepsin is a cell surface serine protease upregulated in prostate cancer.
The functional significance of this upregulation is unknown.  Recent studies
have reported that Hepsin may play a role in the disorganization of the
basement membrane and metastasis.
    Improved screening and early diagnosis have reduced mortality, but the
need exists for treatment options and prognostic markers for advanced
metastatic and hormone resistant disease.  "Hepsin is a promising marker for
prostate cancer since it may help researchers better understand prostate
cancer progression and metastasis," said Angela Thomas, Immunohistochemistry
Product Manager for Signet Laboratories.
    One million men in the United States suffer from prostate cancer.  In 2005
233,000 new cases of prostate cancer will be diagnosed, and over 30,000 men
will die from the disease.

    About Signet Laboratories, Inc.
    Signet Laboratories, Inc. (Signet, Dedham, MA) is a leading medical
diagnostics/research company specializing in the development of monoclonal
antibodies and diagnostic assays for cancer, infectious disease, and
neurodegenerative disease. Signet was created in 1989 as a commercial spinout
of Johnson & Johnson's Cambridge Research Laboratories, Inc. (CRL, Cambridge,
MA).
    The Company was founded to continue the mission originally established at
CRL -- the early detection and recurrence monitoring of patients with cancer
and infectious disease. Signet has developed patented technology for diagnosis
and recurrence monitoring and for risk assessment of asymptomatic patients in
these areas. For more than a decade, the Company has aggressively maintained
licensing and development programs, which are responsible for its broad patent
and intellectual estate.

    Contact Information
    Company Contact                  Immunohistochemistry Contact
    Colleen Scott                    Angela Thomas
    Signet Laboratories, Inc.        Signet Laboratories, Inc.
    180 Rustcraft Road               180 Rustcraft Road
    Dedham, MA 02026                 Dedham, MA 02026
    Phone: 781.915.1404              Phone: 781.915.1417
    Fax:  781.461.2456               Fax:  781.461.2456
    cscott@signetlabs.com            athomas@signetlabs.com


SOURCE Signet Laboratories, Inc.




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Related links:
  • http://www.signetlabs.com
    CONTACT:
    Company Contact: Colleen Scott of Signet
    Laboratories, Inc., +1- 781-915-1404, cscott@signetlabs.com; or
    Immunohistochemistry Contact: Angela Thomas of Signet
    Laboratories, Inc., +1-781-915-1417, athomas@signetlabs.com