Guido Guidetti and Dan Bowman Join Company to Head Commercial Activities In
        The United States and Europe; Key Operations Manager Promoted

    SANTA CLARA, Calif., Dec. 7 /PRNewswire/ -- Applied Imaging Corp.
(Nasdaq: AICX), the leading worldwide provider of automated scanning and
imaging systems for cancer and prenatal cytogenetics, announced today the
appointment of two diagnostic industry veterans to the company's management
team and the promotion of a key executive to the position of Vice President,
Operations.
    Joining the company are Guido Guidetti as Vice President, International
and Dan Bowman as Vice President, the Americas.  In these newly created roles,
Messrs.  Guidetti and Bowman will each have responsibility for all commercial
activities of the company, including sales and customer support, in their
respective regions.
    "I am pleased to announce the appointments of these key executives in our
US and European operations," said Carl Hull, President and Chief Operating
Officer.  "The extensive sales and marketing experience that Dan and Guido
bring will further our focus on the execution of the company's sales plan and
the launch of our newest systems for genetics researchers and for cancer
micrometastasis detection, the Genus(TM) and MDS(TM) Systems."
    Previously, Mr. Guidetti was with International Murex Technologies as
Executive Director, Commercial Operations, a $100 million+ manufacturer of
clinical diagnostic products that was acquired by Abbott Laboratories.  Mr.
Guidetti's extensive health care industry experience includes significant
commercial assignments with Abbott Laboratories and Johnson & Johnson.
    Mr. Bowman was most recently Vice President, Sales for BioGenex, a
developer of automated immunohistochemistry and in situ hybridization
instrumentation.  Mr. Bowman has over 10 years experience in sales, marketing
and general management in the diagnostic products industry with major
companies, including Idexx and Abbott Laboratories.
    In addition, Padraig O'Kelly has been promoted to the position of Vice
President, Operations with responsibility for software product development for
all cytogenetic systems and for manufacturing operations in the United States
and the United Kingdom.  Mr. O'Kelly has been with the company for 7 years and
has played a key role in the development and support of the company's
market-leading CytoVision product line.
    Added Mr. Hull, "The promotion of Paddy O'Kelly to this senior operations
role will allow us to build a functional organization that can fully support
our global efforts going forward.  We are confident that his depth of
knowledge in the company will serve him well in his new role as Vice President
of Operations."

    This press release may contain forward looking statements as defined in
the Private Securities Litigation Reform Act of 1995, regarding, among other
matters, the Company's future financial performance.  Forward looking
statements address matters that are subject to a number of risks and
uncertainties.  Actual results could differ materially from those projected in
the forward-looking statement as a result of a number of factors including the
failure of the Company to successfully develop and commercialize its
micrometastasis or cytogenetic instrument business, and other such factors as
set forth in the Company's form 10K for the year ended December 31, 1998 as
filed with the Securities and Exchange Commission.

    Applied Imaging Corporation, based in Santa Clara, Calif., develops,
manufactures, and markets automated clinical analysis systems used by
laboratories for prenatal and other genetic diseases.  The Company markets its
products worldwide and has more than 800 customer sites in over 35 countries.
Applied Imaging is a publicly traded company listed on the Nasdaq Stock Market
under the Symbol AICX.

    For additional information on Applied Imaging via fax, please dial
1-800-PRO-INFO, (732-544-2850 outside of the U.S.), code AICX.

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