- Agreement Provides Funding Support for Phase 2a Trial -
- Company to Host Conference Call Today at 9:00 a.m. EST -
MONTVALE, N.J., Dec. 20 /PRNewswire-FirstCall/ -- Memory Pharmaceuticals
Corp. (Nasdaq: MEMY) today announced that it has entered into an agreement
with The Stanley Medical Research Institute (SMRI) to develop MEM 1003, the
Company's neuronal L-type calcium channel modulator, as a treatment for
bipolar disorder. Under the terms of the agreement, Memory Pharmaceuticals is
eligible to receive up to $3.2 million from SMRI to fund the clinical
development of MEM 1003 and will use these funds to support a Phase 2a trial
of MEM 1003 in acute mania in bipolar disorder, which is scheduled to commence
in the first half of 2006. Memory Pharmaceuticals also is currently
conducting a Phase 2a clinical trial of MEM 1003 in Alzheimer's disease.
As part of the agreement, SMRI has purchased 440,367 newly issued shares
of the Company's common stock, at a price of $2.18 per share, constituting
$960,000 of the total funding being provided to the Company under the
agreement. In addition, SMRI received a five-year warrant for the purchase of
up to 154,128 additional shares of common stock at an exercise price of $2.62
per share. The Company will receive the remaining $2.24 million of funding
upon the achievement of milestones related to the Phase 2a trial in bipolar
disorder. These funds will be repayable to SMRI in the form of royalties, up
to a specified maximum amount, on future sales of MEM 1003 for the treatment
of bipolar disorder or schizophrenia.
"Abnormal calcium levels are thought to be involved in conditions such as
Alzheimer's disease and bipolar disorder. MEM 1003 regulates calcium
abnormalities and therefore has a solid rationale as a novel potential
therapeutic for such disorders," said David A. Lowe, Ph.D., Chief Scientific
Officer of Memory Pharmaceuticals. "We are delighted to have entered into
this partnership with SMRI, which brings together Memory Pharmaceuticals'
extensive preclinical and clinical experience with MEM 1003 and SMRI's
knowledge and clinical expertise in bipolar disorder. This partnership will
allow us to evaluate the potential of MEM 1003 in bipolar disorder
concurrently with our ongoing Phase 2a clinical program in Alzheimer's
disease."
"The Stanley Medical Research Institute collaborates with academic and
corporate partners to advance the clinical development of promising treatments
for bipolar disorder and schizophrenia," said Michael Knable, Executive
Director of SMRI. "MEM 1003 represents a promising approach to the treatment
of bipolar disorder, and we are pleased to be working with Memory
Pharmaceuticals to take MEM 1003 into a proof-of-concept trial in bipolar
disorder."
MEM 1003 is a neuronal L-type calcium channel modulator that Memory
Pharmaceuticals is developing for the treatment of Alzheimer's disease and
bipolar disorder. By blocking L-type calcium channels, MEM 1003 may regulate
the flow of calcium and reestablish normal levels of calcium, which may
correct or prevent the severe mood swings that characterize bipolar disorder.
Separately, Memory Pharmaceuticals announced today top-line data from its
Phase 1b safety and tolerability study of MEM 1003 for the treatment of
Alzheimer's disease.
Conference Call and Webcast Information
Memory Pharmaceuticals will hold a conference call today at 9:00 a.m. EST
to discuss the SMRI agreement and data from the MEM 1003 Phase 1b safety and
tolerability study. The conference call will also be broadcast live from the
"Investors" section of the Company's Web site.
Jim Sulat, President and Chief Executive Officer, and Dr. David Lowe,
Chief Scientific Officer, will host the conference call.
Investors and other interested parties may access the call as follows:
Date: Tuesday, December 20, 2005
Time: 9:00 a.m. EST
Telephone (U.S.): 800-638-5495
Telephone (international): 617-614-3946
Participant Passcode: 10758595
Webcast: http://www.memorypharma.com under the
"Investors" section
An audio replay of the conference call will be available from 11:00 a.m.
EST on Tuesday, December 20, 2005, until Tuesday, December 27, 2005. To
access the replay, please dial 888-286-8010 (U.S.) or 617-801-6888
(international) and enter passcode number 31705394. An audio replay of the
conference call will also be available under the "Investors" section of the
Company's Web site during the same period.
About the Company
Memory Pharmaceuticals Corp., a biopharmaceutical company, is focused on
developing innovative drugs for the treatment of debilitating CNS disorders
such as Alzheimer's disease, schizophrenia, depression, bipolar disorder,
vascular dementia, mild cognitive impairment, Parkinson's disease and memory
impairments associated with aging. For additional information, please visit
our Web site at http://www.memorypharma.com .
About the Stanley Medical Research Institute
The Stanley Medical Research Institute is the largest private source of
research funding for severe mental illness. SMRI supports research in
academic and corporate environments that is directly linked to discovering new
treatments for bipolar disorder and schizophrenia. Further information about
SMRI can be obtained at http://www.stanleyresearch.org .
Safe Harbor Statement
This press release contains forward-looking statements within the meaning
of the Private Securities Litigation Reform Act of 1995 that are subject to
risks and uncertainties. All statements, other than statements of historical
facts, regarding management's expectations, beliefs, goals, plans or Memory
Pharmaceuticals' prospects, future financial position, future revenues and
projected costs should be considered forward-looking. Readers are cautioned
that actual results may differ materially from projections or estimates due to
a variety of important factors, including the risks and uncertainties
associated with: Memory Pharmaceuticals' ability to enter into and maintain
collaborations with third parties for its drug development programs; Memory
Pharmaceuticals' dependence on its collaborations and its license relationship
with Bayer; conducting preclinical and clinical trials of Memory
Pharmaceuticals' drug candidates that demonstrate these candidates' safety and
effectiveness; obtaining regulatory approvals to conduct clinical trials and
to commercialize Memory Pharmaceuticals' drug candidates; achieving milestones
under Memory Pharmaceuticals' collaborations; obtaining additional financing
to support Memory Pharmaceuticals' R&D and clinical activities and operations;
Memory Pharmaceuticals' dependence on third-party preclinical or clinical
research organizations, manufacturers and consultants; and protecting the
intellectual property developed by or licensed to Memory Pharmaceuticals.
These and other risks are described in greater detail in Memory
Pharmaceuticals' filings with the Securities and Exchange Commission. Memory
Pharmaceuticals may not actually achieve the goals or plans described in its
forward-looking statements, and investors should not place undue reliance on
these statements. Memory Pharmaceuticals disclaims any intent or obligation to
update any forward-looking statements as a result of developments occurring
after the date of this press release.
SOURCE Memory Pharmaceuticals Corp.
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Related links:
http://www.memorypharmaceuticals.com
http://www.stanleyresearch.org
CONTACT:
Jzaneen Lalani, Vice President, Legal Affairs
of Memory Pharmaceuticals, +1-201-802-7249, Laura Perry of Stern
Investor Relations, Inc., +1-212-362-1200
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