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Trega Biosciences Reports First-Quarter 1997 Results

    SAN DIEGO, May 15 /PRNewswire/ -- Trega Biosciences, Inc. (Nasdaq: TRGA)
(formerly Houghten Pharmaceuticals, Inc.; Nasdaq: HPIP) today reported
financial results for the first quarter ended March 31, 1997.  Revenues for
the first quarter were $1.4 million, compared with revenues of $1.6 million in
the same period for 1996.  The net loss for the first quarter of 1997 was $1.4
million, or $0.11 per share, based on 13.4 million weighted shares
outstanding, compared with a net loss of $1.8 million, or $0.19 per share,
based on 9.7 million weighted shares outstanding, in the comparable period in
1996.  The results for the first quarter of 1997 include a gain of $1.3
million, or $0.09 per share, in connection with the sale of Multiple Peptide
Systems, Inc. (MPS).  Trega ended the quarter with $25.7 million in cash, cash
equivalents and short-term investments.
    Revenues in the first quarter resulted primarily from collaborative
agreements related to the company's combinatorial libraries, which are used by
pharmaceutical and biotechnology companies as a source of potential new drug
leads.  Additional revenues were generated by Trega's former subsidiary, MPS,
which manufactures and markets custom peptides.
    "During the quarter, we signed a drug discovery agreement with Chugai
Biopharmaceuticals, Inc.," noted Robert S. Whitehead, president and chief
executive officer.  "This partnership with Chugai is unique in that we
combined the best of our funding and joint discovery business strategies with
technology transfer to create an alliance that provides near-term revenues and
a range of potential long-term benefits."
    "We also have continued the aggressive development of our internal
melanocortin receptor screening program and have begun screening our inventory
of over 2.3 million small-molecules to discover additional drug leads,"
continued Whitehead.  "Our research indicates that melanocortin receptors may
be important for the identification of drugs for the treatment of
inflammatory, metabolic and other diseases."
    Research and development expenses increased to $2.8 million in the first
quarter of 1997, compared with $2.2 million in the same quarter last year.
The increase in expenses was due principally to increased funding for the
company's combinatorial chemistry program.  Selling, general and
administrative expenses increased to $1.3 million in the first quarter of 1997
from $0.8 million in the comparable period last year, due primarily to higher
legal costs and increased costs associated with being a public company.
    Trega Biosciences is a drug discovery company, utilizing combinatorial
chemistry and other technologies to pursue the discovery of novel, small-
molecule drug therapies.  The company leverages its technology platform by
entering into pharmaceutical alliances, enabling partners to access Trega's
technologies in exchange for licensing fees and potential milestone payments
and royalties, or by establishing joint-discovery alliances with biotechnology
companies.  Trega also uses its drug discovery technologies in its internal
development programs.  HP 228, the company's lead compound, is in Phase II
trials for the treatment of inflammatory and metabolic diseases.
    Except for the historical information contained herein, the matters
discussed in this news release are forward-looking statements that involve
risks and uncertainties, including whether any proposed product can be
successfully formulated, scaled-up, developed and commercialized, whether
regulatory approvals can be obtained, the impact of competitive products and
pricing, whether any corporate collaborations or alliances will be successful,
and other risks detailed from time to time in Trega's Securities and Exchange
Commission (SEC) filings.  These forward-looking statements represent Trega's
judgment as of the date of this release.  Actual results may differ materially
from those projected.  Trega disclaims, however, any intent or obligation to
update these forward-looking statements.

                           TREGA BIOSCIENCES, INC.
               Condensed Consolidated Statements of Operations
                    (in thousands, except per share data)

                                                            Three Months Ended
                                                                March 31,
                                                            1997        1996
                                                               (unaudited)
   Revenues:
     Net sales                                               $430       $561
     Contract research                                        946      1,004

   Total revenues                                           1,376      1,565

   Operating expenses:
     Cost of sales                                            319        467
     Research and development                               2,845      2,166
     Acquired in-process R&D                                    4          -
     Selling, general and administrative                    1,291        795

   Total operating expenses                                 4,459      3,428

   Loss from operations                                   (3,083)    (1,863)

   Other income:
     Other income                                              67          -
     Interest income, net                                     314         52
     Gain on sale of MPS                                    1,259          -

   Net loss                                              $(1,443)   $(1,811)
   Net loss per share                                     $(0.11)    $(0.19)
   Weighted average shares                                 13,412      9,698

                             TREGA BIOSCIENCES, INC.
                      Condensed Consolidated Balance Sheets
                      (in thousands, except per share data)

                                                        March 31,   Dec. 31,
                                                             1997       1996
   ASSETS                                             (unaudited)
   Current assets:
     Cash, cash equivalents and short-term investments    $25,692    $27,443
     Accounts receivable                                      703        481
     Notes receivable                                       1,000          -
     Other current assets                                      58        282
   Total current assets                                    27,453     28,206

   Property and equipment, net                              1,702      1,745
   Notes receivable (long-term)                               541          -
   Other assets                                               555        562
   Total assets                                           $30,251    $30,513

   LIABILITIES AND STOCKHOLDERS' EQUITY
   Current liabilities:
     Accounts payable                                        $886       $810
     Accrued liabilities                                    1,102      2,720
     Current portion of capital lease obligations             367        433
     Deferred revenue                                       4,290      1,761
   Total current liabilities                                6,645      5,724
   Obligations under capital leases                           492        633
   Total liabilities                                        7,137      6,357

   Stockholders' equity:
     Common stock                                              13         13
     Additional paid-in capital                            71,285     71,050
     Common stock issuable                                  1,281      1,281
     Deferred compensation, net                           (1,766)    (1,931)
     Accumulated deficit                                 (47,699)   (46,257)
   Total stockholders' equity                              23,114     24,156
   Total liabilities and stockholders' equity             $30,251    $30,513


SOURCE Trega Biosciences Inc.




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CONTACT:
Noel M. Byczek, Director of Corporate
Communications for Trega Biosciences, 619-455-2877