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Houghten Pharmaceuticals Reports Second Quarter 1996 Results

    SAN DIEGO, Aug. 13 /PRNewswire/ -- Houghten Pharmaceuticals, Inc. (HPI)
(Nasdaq: HPIP) today reported financial results for its second quarter ended
June 30, 1996.  The net loss for the second quarter 1996 was $3.0 million, or
$0.23 per share, compared with a net loss of $2.1 million, or $0.22 per share
reported for the second quarter 1995.  For the six months ended June 30, 1996,
the company reported a net loss of $4.9 million, or $0.43 per share, compared
with $3.7 million, or $0.38 per share for the comparable period in 1995.  The
change in net loss for both periods reported was primarily due to increased
research and development expenses used to fund the expansion of HPI's internal
combinatorial chemistry program and costs associated with continued
development of HPI's lead compound, HP 228, currently in clinical trials for
the treatment of diabetes and obesity.
    "During the quarter we made significant advancements toward enhancing our
position in the molecular diversity field," noted Robert S. Whitehead,
president and chief executive officer.  He continued, "We expanded our
technical expertise by adding experienced pharmaceutical industry scientists
to design advanced generation robotics systems for automated synthesis of
small molecule combinatorial libraries.  We also increased the depth of our
diversity capabilities by signing an agreement to acquire the ChromaXome
Corporation.  ChromaXome's combinatorial biology technology positions HPI to
be a leading resource for potentially very diverse compounds, especially those
created from natural sources that historically have been too expensive and
difficult to access."
    Revenues for the second quarter 1996 were $0.9 million compared with
revenues of $0.5 million in the second quarter 1995.  For the six months ended
June 30, 1996 revenues increased to $2.5 million compared with $0.5 million
for the six month period ended June 30, 1995.  Growth in revenues, on a year-
to-date basis, resulted primarily from higher shipments of combinatorial
chemistry libraries to HPI's corporate collaborators for use in their drug
discovery programs as well as from HPI's wholly owned subsidiary, Multiple
Peptide Systems (MPS), which manufactures and markets custom peptides to the
research community.  Figures for the first six months of 1995 include only
three months of operating results from MPS.
    HPI ended the quarter with $32 million in cash and short-term investments.
    HPI utilizes combinatorial chemistry to pursue the discovery of novel,
small-molecule drug therapies.  Combinatorial chemistry is a technology for
the synthesis, identification and optimization of lead compounds that can
significantly shorten the time required for, and reduce the costs associated
with, drug discovery.  The company uses its molecular diversity technologies
for internal discovery programs, as well as in collaboration with
pharmaceutical companies in exchange for fees and potential milestone payments
and royalties.  In addition, HPI develops joint-discovery alliances with
biotechnology firms and retains certain product ownership rights.
    Except for the historical information contained herein, the matters
discussed in the news release are forward-looking statements that involve
risks and uncertainties, including whether any proposed product can be
successfully formulated, scaled-up, developed and commercialized, whether
regulatory approvals can be obtained, the impact of competitive products and
pricing, whether any corporate collaborations will be successful, and other
risks detailed from time to time in HPI's Securities and Exchange Commission
(SEC) filings.  These forward-looking statements represent HPI's judgment as
of the date of this release.  Actual results may differ materially from those
predicted.  HPI disclaims, however, any intent or obligation to update these
forward-looking statements.

                        HOUGHTEN PHARMACEUTICALS, INC.
                      Condensed Statement of Operations
                                 (unaudited)

                                 Three Months Ended        Six Months Ended
                                      June 30,                 June 30,
                                  1996        1995         1996        1995
    Revenues:
    Net sales                $890,429     $521,045  $2,455,481     $534,045

    Operating expenses:
    Cost of sales             482,552      406,398     949,403      412,398
    Research and development3,002,911    1,579,227   5,169,083    3,116,909
    Selling, general and
     administrative           866,512      639,509   1,661,602    1,130,453
    Total operating expenses4,351,975    2,625,134   7,780,088    4,659,760
    Loss from operations  (3,461,546)  (2,104,089) (5,324,607)  (4,125,715)
    Interest and other
     income/(expense), net    413,807       25,170     466,287      430,348
    Net loss             $(3,047,739) $(2,078,919)$(4,858,320) $(3,695,367)
    Net loss per share        $(0.23)      $(0.22)     $(0.43)      $(0.38)
    Weighted average common
     and common equivalent
     shares                13,000,939    9,658,302  11,349,378    9,631,426

                        HOUGHTEN PHARMACEUTICALS, INC.
                           Condensed Balance Sheet

                                                    June 30,      December 31,
                                                      1996           1995
                                                  (unaudited)
    ASSETS
    Current assets:
    Cash, cash equivalents and short
     term investments                         $32,157,062      $1,160,776
    Accounts receivable                           419,225         241,076
    Other current assets                          395,037         131,921
    Total current assets                       32,971,324       1,533,773
    Property and equipment, net                   836,875         934,586
    Other assets                                  438,762         277,097
                                              $34,246,961      $2,745,456

    LIABILITIES AND STOCKHOLDERS' EQUITY (DEFICIT)
    Current liabilities:
    Accounts payable                             $469,811        $216,307
    Accrued liabilities                         1,992,472       1,297,907
    Current portion of capital lease obligations  361,842         361,151
    Other liabilities                           2,711,772       2,003,532
    Total current liabilities                   5,535,897       3,878,897
    Obligations under capital leases              315,587         470,301
    Redeemable preferred stock                        ---       2,772,000
    Total liabilities                           5,851,484       7,121,198
    Stockholders' equity (deficit):
    Convertible preferred stock                       ---          15,931
    Common stock                                   13,145             310
    Additional paid-in capital                 69,685,024      30,366,418
    Deferred compensation, net                (1,875,151)       (236,000)
    Accumulated deficit                      (39,427,541)    (34,522,401)
    Total stockholders' equity (deficit)       28,395,477     (4,391,673)
                                              $34,246,961      $2,729,525


SOURCE Houghten Pharmaceuticals, Inc.




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CONTACT:
Terence E. McMorrow, CFO, 619-455-2864, or
Noel M. Byczek, Manager of Corporate Communications of Houghten
Pharmaceuticals, 619-455-2877