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Trega Biosciences Reports Second-Quarter 1997 Results

    SAN DIEGO, Calif., Aug. 14 /PRNewswire/ -- Trega Biosciences, Inc.
(Nasdaq: TRGA) today reported financial results for the second quarter and the
six-month period ended June 30, 1997.  Revenues for the second quarter were
$2.6 million, compared with revenues of $0.9 million in the same period for
1996.  The net loss for the second quarter of 1997 was $2.1 million, or $0.16
per share, compared with a net loss of $3.0 million, or $0.23 per share, in
the comparable period in 1996.  Trega ended the quarter with $24.2 million in
cash, cash equivalents and short-term investments.
    Revenues in the second quarter resulted primarily from collaborative
agreements related to the company's combinatorial libraries, which are used by
pharmaceutical and biotechnology companies as a source of potential new drug
leads.
    "During the quarter, we signed a milestone agreement with Ono
Pharmaceuticals of Osaka, Japan," stated Robert S. Whitehead, president and
chief executive officer.  "This is the first collaboration that links our
combinatorial chemistry expertise with our expanding research in the area of
melanocortin receptors.  Using our dual chemistry and biology capabilities, we
are working with Ono to discover orally active, melanocortin-1-receptor
specific, small-molecule drugs for inflammatory disorders.  We look forward to
structuring additional agreements with pharmaceutical companies surrounding
other melanocortin receptors, such as melanocortin 4, which has been linked to
diabetes and obesity."
    Research and development expenses increased to $3.4 million in the second
quarter of 1997, compared with $3.0 million in the same quarter last year.
The increase in expenses was due principally to increased funding for the
company's combinatorial chemistry program.  Selling, general and
administrative expenses increased to $1.6 million in the second quarter of
1997 from $0.9 million in the comparable period last year, due primarily to
higher legal costs incurred for litigation, patents and corporate development
activities.
    For the six months ended June 30, 1997, total revenues were $3.9 million,
compared with $2.5 million for same period last year.  The net loss for the
six months was $3.6 million, or $0.27 per share, compared with $4.9 million,
or $0.43 per share, for the six months ended June 30, 1996.
    Trega Biosciences is a drug discovery company, utilizing combinatorial
chemistry and other technologies to pursue the discovery of novel, small-
molecule drug therapies.  The company leverages its technology platform by
entering into pharmaceutical alliances, enabling partners to access Trega's
technologies in exchange for licensing fees and potential milestone payments
and royalties, or by establishing joint-discovery alliances with biotechnology
companies.  Trega also uses its drug discovery technologies in its internal
development programs.  HP 228, the company's lead compound, is in Phase II
trials for the treatment of inflammatory diseases.
    Except for the historical information contained herein, the matters
discussed in this news release are forward-looking statements that involve
risks and uncertainties, including whether any proposed product can be
successfully formulated, scaled-up, developed and commercialized, whether
regulatory approvals can be obtained, the impact of competitive products and
pricing, whether any corporate collaborations or alliances will be successful,
and other risks detailed from time to time in Trega's Securities and Exchange
Commission (SEC) filings.  These forward-looking statements represent Trega's
judgment as of the date of this release.  Actual results may differ materially
from those projected.  Trega disclaims, however, any intent or obligation to
update these forward-looking statements.


                              TREGA BIOSCIENCES, INC.
                       Condensed Consolidated Balance Sheets
                       (in thousands, except per share data)

                                           June 30,          December 31,
                                             1997                1996
    ASSETS                               (unaudited)
      Current assets:
        Cash, cash equivalents and
         short-term investments            $24,176             $27,443
        Accounts receivable                     56                 481
        Notes receivable                       516                 ---
        Other current assets                   737                 282
      Total current assets                  25,485              28,206

    Property and equipment, net              2,147               1,745
    Notes receivable (long-term)               549                 ---
    Other assets                             1,833                 562
    Total assets                           $30,014             $30,513

    LIABILITIES AND STOCKHOLDERS' EQUITY
      Current liabilities:
        Accounts payable                      $741                $810
        Accrued liabilities                  1,774               2,720
        Current portion of capital
         lease obligations                     171                 433
        Current portion of notes               268                 ---
        Deferred revenue                     3,841               1,761
    Total current liabilities                6,795               5,724
    Obligations under capital leases           428                 633
    Long-term notes payable                  1,522                 ---
    Total liabilities                        8,745               6,357

    Stockholders' equity:
        Common stock                            13                  13
        Additional paid-in capital          71,402              71,050
        Common stock issuable                1,281               1,281
        Deferred compensation, net         (1,601)             (1,931)
        Accumulated deficit               (49,826)            (46,257)
    Total stockholders' equity              21,269              24,156
    Total liabilities and
     stockholders' equity                  $30,014             $30,513


                              TREGA BIOSCIENCES, INC.
                  Condensed Consolidated Statements of Operations
                                    (Unaudited)
                       (in thousands, except per share data)

                                      Three Months Ended   Six Months Ended
                                           June 30,            June 30,
                                        1997       1996      1997     1996

    Revenues:
      Net sales                        $---       $553       $430    $1,113
      Contract research and
       licenses fees                  2,568        337      3,514     1,342

    Total revenues                    2,568        890      3,944     2,455

    Operating expenses:
      Cost of revenues                   22        483        341       949
      Research and development        3,384      3,003      6,229     5,169
      In process research
       and development                  ---        ---          4       ---
      Selling, general and
       administrative                 1,620        866      2,911     1,662
    Total operating expenses          5,026      4,352      9,485     7,780
    Loss from operations            (2,458)   $(3,462)   $(5,541)  $(5,325)
    Interest and other
     income/(expense), net              332        414      1,972       467
    Net loss                       $(2,126)   $(3,048)   $(3,569)  $(4,858)
    Net loss per share              $(0.16)    $(0.23)    $(0.27)   $(0.43)
    Weighted average common and
     common equivalent shares        13,466     13,001     13,439    11,349


SOURCE Trega Biosciences, Inc.




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CONTACT:
Noel M. Wheeler, Director, Corporate
Communications for Trega Biosciences, Inc., 619-455-2877