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Shire Pharmaceuticals Group plc

    ANDOVER, England, Feb. 17 /PRNewswire/ -- Shire Pharmaceuticals Group plc
("Shire") (Nasdaq: SHPGY; London: SHP.L) today releases historic proforma
data, in US GAAP format, to assist the market with the interpretation of the
Group's key financial statements following the recent merger with Roberts
Pharmaceuticals Corporation.  Shire previously reported according to UK GAAP
but following this merger will be reporting in US GAAP.
    This information is provided in advance of Shire's results for the
following periods which will be announced on Tuesday, 29 February 2000 at 12pm
UK (7am US ET):

    1.    Preliminary results for the year ended 31 December 1999 and fourth
          quarter results for the three months ended 31 December 1999.

    2.    Income statement (unaudited) for January 2000 (these results are
          being published early to comply with certain SEC regulations
          following the recent merger with Roberts Pharmaceutical
          Corporation).

    Shire Pharmaceuticals Group plc
    Shire is an international specialty pharmaceutical company with a
strategic focus on four therapeutic areas; central nervous system disorders,
metabolic diseases, oncology and gastroenterology.  Shire has a sales and
marketing infrastructure with a broad portfolio of products targeting the US,
Canada, UK, Republic of Ireland, France, Germany and Italy, with plans to add
other key markets in due course.  Shire's global search and development
expertise has already provided three marketed products, whilst the current
pipeline of 15 projects includes one project in registration and five at Phase
III.   Shire is actively searching to acquire further marketed products and
development projects to enhance the potential for future growth, both
organically and by acquisition.

    THE "SAFE HARBOR" STATEMENT UNDER THE PRIVATE SECURITIES LITIGATION REFORM
ACT OF 1995.  The statements in this press release that are not historical
facts are forward-looking statements that involve risks and uncertainties,
including but not limited to, risks associated with the inherent uncertainty
of pharmaceutical research, product development and commercialization, the
impact of competitive products, patents, and other risks and uncertainties,
including those detailed from time to time in periodic reports, including the
F-4 Prospectus and the Annual Report filed on Form 20-F with the Securities
and Exchange Commission.

    BASIS OF PREPARATION:

    (1)   The unaudited pro forma combined income statements give effect to
          the merger of Shire and Roberts Pharmaceutical Corporation as a
          pooling of interests under U.S. GAAP. They are presented in both US
          dollars and pounds sterling. The results for all periods presented
          are prepared under U.S. GAAP.  A reconciliation of the U.S. GAAP
          pound sterling denominated income statement to UK GAAP is included
          within the pound sterling financial information.

    (2)   The results for the years ended December 31, 1995 and 1996 are
          prepared from the results on Form10K for Roberts and the unaudited
          results of Shire.  The results of Shire for the years ended December
          31, 1995 and 1996 have not been audited as these were not statutory
          periods.  During 1997 Shire's year end was changed from 30 June to
          31 December.

    (3)   The results for the years ended December 31, 1997 and 1998 are
          prepared from the results on Form 10K for Roberts and the Audited
          Consolidated Financial Statements of Shire, as restated in U.S.
          GAAP.

    (4)   The results for the nine months ended September 30, 1999 are
          prepared from the results of Roberts on Form 10Q and from Shire's
          unaudited quarterly report.

    (5)   Pro forma weighted average ordinary shares have been calculated
          using the exchange ratio of 3.1280, representing the number of
          ordinary shares issued for each Roberts share under the terms of the
          merger agreement.

    (6)   Exchange rates used in the preparation of this financial information
          are detailed within these schedules.


    Pro Forma Combined Income Statements

               Year ended   Year ended   Year ended   Year ended 9 months to
                   31 Dec       31 Dec       31 Dec       31 Dec     30 Sept
                     1995         1996         1997         1998        1999
                    $'000        $'000        $'000        $'000       $'000

    Revenues:
    Product
     sales        124,352      115,524      168,916      291,785     283,346
    Licensing and
     development   12,895       11,406       20,130       11,821       9,771
    Royalties         330          806        1,612        3,697       2,318
    Other revenue      47           36          896        1,681       1,708

    Total sales
     and revenue  137,624      127,772      191,554      308,984     297,143

    Costs and expenses:
    Cost of
     sales         56,849       57,552       67,090       95,013      69,143
    Research and
     development   15,533       22,979       40,663       59,253      51,516
    Selling, general
     and
     administr-
     ative         49,577       60,843       74,246      106,453     105,377
    Other charges:
    Intangible write-offs
     and loss/(gain)
     on dispositions   --       33,906           --        (220)          --
    In process research and
    Development    23,275           --       83,087           --          --

    Total operating costs
     and
     expenses     145,234      175,280      265,086      260,499     226,036
    EBITDA        (7,610)     (47,508)     (73,532)     (48,485)      71,107
    Depreciation &
     amortization (7,441)      (7,806)     (12,309)     (25,249)    (19,519)
    Operating
     income      (15,051)     (55,314)     (85,841)       23,236      51,588

    Other income/(expense)
    Interest
     income         2,202        4,811        6,547        6,398       5,375
    Interest
     expense      (5,688)      (1,763)        (964)      (6,511)     (7,290)
    Other, net         49          188      (2,474)          440        (96)

    Total other income/
     (expense)    (3,437)        3,236        3,109          327     (2,011)

    Income from continuing
     operations
     before
     taxes       (18,488)     (52,078)     (82,732)       23,563      49,577

    Income taxes  (2,518)       15,815      (1,420)      (2,991)    (20,609)

    Income/(loss)
     from continuing
     operations  (21,006)     (36,263)     (84,152)       20,572      28,968

    Income from
     discontinued
     operations,
     net of tax  (27,045)          556           --           --          --

    Net income   (48,051)     (35,707)     (84,152)       20,572      28,968

    Net income per share:
     Basic         (0.58)       (0.30)       (0.45)         0.09        0.12
     Diluted       (0.58)       (0.30)       (0.45)         0.08        0.12

    Weighted average
     number of common
     shares
     outstanding:
      Basic    83,082,819  118,766,218  185,153,065  234,044,732 241,977,657
      Diluted  83,082,819  118,766,218  185,153,065  242,806,410 249,505,550

    Pro Forma Combined Income Statement

    Quarterly data 1999    Quarter       Quarter      Quarter      9 months
                          31 March       30 June 30 September  30 September
                             $'000         $'000        $'000         $'000

    Revenues:
     Product sales          87,756        93,099      102,491       283,346
     Licensing and
      development            6,411         1,336        2,024         9,771
     Royalties                 629         1,141          548         2,318
     Other revenue             456           531          721         1,708

    Total sales
     and revenue            95,252        96,107      105,784       297,143

    Costs and expenses:
     Cost of sales          23,511        19,229       26,403        69,143
     Research and
      development           16,279        15,369       19,868        51,516
     Selling, general and
      administrative        34,660        35,840       34,877       105,377
    Other charges:
     Intangible write-offs and
      loss/(gain)
      on dispositions           --            --           --            --
    In process research
     and development            --            --           --            --

    Total operating costs
     and expenses           74,450        70,438       81,148       226,036
    EBITDA                  20,802        25,669       24,636        71,107
    Depreciation &
     amortization          (6,275)       (6,274)      (6,970)      (19,519)
    Operating income        14,527        19,395       17,666        51,588

    Other income/(expense)
    Interest income          1,613         2,001        1,761         5,375
    Interest expense       (2,558)       (2,335)      (2,397)       (7,290)
    Other, net                 650         (522)        (224)          (96)

    Total other income/
     (expense)               (295)         (856)        (860)       (2,011)

    Income before taxes     14,232        18,539       16,806        49,577

    Income taxes           (3,966)       (9,130)      (7,513)      (20,609)

    Net income              10,266         9,409        9,293        28,968

    Net income per share:
     Basic                    0.04          0.04         0.04          0.12
     Diluted                  0.04          0.04         0.04          0.12

    Weighted average number of
     common shares outstanding:
      Basic            240,438,985   242,149,929  243,312,483   241,977,657
      Diluted          247,390,800   248,264,519  251,446,294   249,505,550

    Pro Forma Combined Income Statement

    Quarterly data 1998
                  Quarter      Quarter      Quarter      Quarter   12 months
                 31 March      30 June 30 September  31 December 31 December
                    $'000        $'000        $'000        $'000       $'000

    Revenues:
    Product sales  60,681       73,821       68,073       89,210     291,785
    Licensing and
     development    2,315        3,920          757        4,829      11,821
    Royalties         724        1,424          578          971       3,697
    Other revenue     259          568          378          476       1,681

    Total sales
     and revenue   63,979       79,733       69,786       95,486     308,984

    Costs and expenses:
    Cost of
     sales         18,670       21,942       22,743       31,658      95,013
    Research and
     development   14,676       16,143       11,380       17,054      59,253
    Selling, general and
     administr-
     ative         27,085       29,320       24,156       25,892     106,453

    Other charges:
    Intangible write-offs and
     loss/(gain) on
     dispositions      --           --           --        (220)       (220)
    In process research and
    development        --           --           --           --          --

    Total operating costs
     and expenses  60,431       67,405       58,279       74,384     260,499
    EBITDA          3,548       12,328       11,507       21,102      48,485
    Depreciation &
     amortization (5,250)      (6,695)      (6,546)      (6,758)    (25,249)
    Operating
     income       (1,702)        5,633        4,961       14,344      23,236

    Other income/(expense)
    Interest
     income         1,434        1,748        1,375        1,841       6,398
    Interest
     expense        (476)        (239)      (3,056)      (2,740)     (6,511)
    Other, net        435          410          686      (1,091)         440

    Total other
     income/
     (expense)      1,393        1,919        (995)      (1,990)         327

    Income before
     taxes          (309)        7,552        3,966       12,354      23,563

    Income taxes  (4,919)          502          939          487     (2,991)

    Net income    (5,228)        8,054        4,905       12,841      20,572

    Net income per share:
     Basic         (0.02)         0.03         0.02         0.05        0.09
     Diluted       (0.02)         0.03         0.02         0.05        0.08

    Weighted average
    number of common
    shares outstanding:
     Basic    221,453,169  236,799,603  238,478,589  239,259,296 234,044,732
     Diluted  221,453,169  245,869,067  246,095,575  248,223,566 242,806,410

    PRO FORMA COMBINED BALANCE SHEET

                                   31 Dec                 30 Sept
                                     1998                    1999
                                    $'000                   $'000
    ASSETS

    Current assets
    Cash and cash equivalents      52,973                  36,603
    Marketable securities          36,062                  31,897
    Current asset investments      35,664                  81,141
    Inventories                    34,639                  41,699
    Accounts receivable, net       74,253                  72,266
    Notes receivable                2,369                   6,259
    Other current assets           39,578                  28,735

    Total current assets          275,538                 298,600

    Property & equipment, net      42,682                  42,676
    Intangible assets             537,159                 569,730
    Other assets                   18,226                  32,314

     Total assets                 873,605                 943,320

    LIABILITIES AND SHAREHOLDERS EQUITY

    Current liabilities
    Current installments of
     long term debt                12,351                  16,699
    Account payable                54,896                  49,944
    Other current liabilities      14,041                  37,418

    Total current liabilities      81,288                 104,061

    Long term debt, excluding
     current installments         126,774                 125,188
    Other long term liabilities     2,229                   2,282

    Total liabilities             210,291                 231,531

    Shareholders' equity          663,314                 711,789

    Total liabilities and
     shareholders' equity         873,605                 943,320


    Pro Forma Combined Statements of Cash flows

                                 Year ended      Year ended   9 months to
                                     31 Dec          31 Dec       30 Sept
                                       1997            1998          1999
                                      $'000           $'000         $'000

    Cash flows from
    operating activities:
     Net income/(loss)             (84,152)          20,573        28,968
     Adjustments to reconcile net
     income/(loss) to net cash
     flows from operating activities
      Depreciation and
       amortization                  12,309          25,249        19,519
      Non qualifying stock option
       compensation cost              2,567           8,505        13,581
      Non cash exchange
       gains and losses             (1,289)         (1,817)           332
      (Profit)/loss on sale of
       fixed assets                    (13)              16         (828)
      (Increase)/decrease
       in inventory                 (4,657)         (5,170)       (7,060)
      (Increase)/decrease in
       accounts receivable          (5,751)        (24,988)      (10,247)
      Increase/(decrease)
       in accounts payable              511          12,186        18,388
      Carbatrol milestone payment     8,000              --            --
      Impact of discontinued
       operations                     (629)              --            --
      Acquisition of in-process
       research and development      83,087              --            --

    Net cash provided by/(used in)
     operating activities             9,983          34,554        62,653

    Cash flows from
    investing activities:
     Redemption of/(investment in)
      marketable securities        (32,094)           3,825         4,165
     Purchase of long
      term investment                    --        (10,000)            --
     Deferred consideration        (10,000)              --            --
     Purchase of subsidiary
      undertakings                 (41,053)              --            --
     Expenses of acquisition        (3,118)           (551)            --
     Net cash acquired with
      subsidiary undertakings         6,759              --            --
     Purchase of intangible
      assets                       (10,066)       (142,258)      (40,299)
     Purchase of fixed assets      (13,936)        (13,871)       (4,311)
     Sale of intangible
      fixed assets                       --           1,033            --
     Sale of fixed assets                20              60         1,407
     Collection on
      notes receivable                6,738           1,751         5,536

    Net cash provided by/
     (used in) investing
     activities                    (96,750)       (160,011)      (33,502)

    Cash flows from
    financing activities:
     (Increase)/decrease in cash
      placed on short-term deposit   33,949        (35,664)      (45,477)
    Long term debt issued                --         125,000            --
    Payments on long term debt,
     capital leases and notes
     payable                        (7,410)        (11,708)       (8,241)
    Payment on debt issuance costs       --         (2,528)            --
    Proceeds from issue
     of common stock, net            19,054          35,027         4,834
    Proceeds from exercise
     of stock options                 1,016           4,082         3,295
    Proceeds from issue
     of preferred stock               6,000           4,494            --
    Cash dividends paid             (1,629)           (150)            --

    Net cash provided by/(used in)
     financing activities            50,980         118,553      (45,589)

    Effect of exchange rate changes
     on cash and cash equivalents     (401)               9            68

    Net increase/(decrease) in cash
     and cash equivalents          (36,188)         (6,895)      (16,370)

    Cash and cash equivalents at
     beginning of year               96,057          59,868        52,973

    Cash and cash equivalents
     at end of year                  59,869          52,973        36,603


    NET PRODUCT SALES DATA

                          Q1         Q2      Q3       Q4       YTD
                        1999       1999    1999     1999      1999     % of
                       $'000      $'000   $'000    $'000     $'000    Total

    ADDERALL          31,547     29,159  36,046             96,752      34%
    PENTASA           15,002      8,555  20,194             43,751      15%
    AGRYLIN            5,169     19,194   4,015             28,378      10%
    PROAMATINE         5,858      1,801   8,382             16,041       6%
    CALCIUMS           4,027      4,219   4,211             12,457       4%
    DEXTROSTAT         1,944      2,550   2,153              6,647       2%
    CARBATROL          2,601      3,812   4,250             10,663       4%

    OTC                6,164      4,823   8,005             18,992       7%

    OTHERS            15,444     18,986  15,235             49,665      18%
                      87,756     93,099 102,491        0   283,346     100%


    NET PRODUCT SALES DATA


                          Q1         Q2      Q3       Q4     Total
                        1998       1998    1998     1998      1998     % of
                       $'000      $'000   $'000    $'000     $'000    Total

    ADDERALL          16,320     19,365  15,298   22,997    73,980      25%
    PENTASA               --     13,441   7,480   12,403    33,324      11%
    AGRYLIN            3,567      5,071  10,977    4,114    23,729       8%
    PROAMATINE         3,002      2,506   4,871    5,034    15,413       5%
    CALCIUMS           3,141      3,551   3,696    4,220    14,608       5%
    DEXTROSTAT         1,471      1,541   1,359    1,629     6,000       2%
    CARBATROL          2,677      1,032     495    1,131     5,335       2%

    OTC                6,273      7,666   4,843    7,178    25,960       9%

    OTHERS            24,230     19,648  19,054   30,504    93,436      32%
                      60,681     73,821  68,073   89,210   291,785     100%


    Pro Forma Combined Income Statement

               Year ended   Year ended   Year ended   Year ended 9 months to
                   31 Dec       31 Dec       31 Dec       31 Dec    30 Sept.
                     1995         1996         1997         1998        1999
              '000 pounds  '000 pounds  '000 pounds  '000 pounds '000 pounds

    Revenues:
     Product
      sales        78,689       73,428      102,870      175,543     175,216
     Licensing and
      development   8,160        7,250       12,064        7,083       6,034
     Royalties        209          512        1,031        2,223       1,442
     Other revenue     30           23          546        1,011       1,057

    Total sales
     and revenue   87,088       81,213      116,511      185,860     183,749

    Costs and expenses:
     Cost of
      sales        35,974       36,580       40,900       57,131      42,729
     Research and
      development   9,829       14,606       24,736       35,650      31,913
     Selling, general and
      administ
      -rative      31,372       38,439       45,889       63,905      65,159
    Other charges:
     Intangible
      write-offs       --       21,551           --           --          --
     In process
      research and
      development  14,728           --       50,626           --          --

    Total operating
     costs and
     expenses      91,903      111,176      162,151      156,686     139,801

    EBITDA        (4,815)     (29,963)     (45,640)       29,174      43,948

    Depreciation
     and amorti
     -zation      (4,709)      (4,962)      (7,485)     (15,281)    (12,068)

    Operating
     income       (9,524)     (34,925)     (53,125)       13,893      31,880

    Other income/(expense)
     Interest
      income        1,393        3,058        3,994        3,850       3,326
     Interest
      expense     (3,599)      (1,120)        (586)      (3,909)     (4,506)
     Foreign
      currency         --           --         (66)          278       (323)
     Other, net        31          120      (1,439)         (40)         253

    Total other income/
     (expense)    (2,175)        2,058        1,903          180     (1,250)

    Income from
     continuing operations
     before
     taxes       (11,699)     (32,867)     (51,222)       14,073      30,630

    Income taxes  (1,593)        9,097        (849)      (1,848)    (12,767)

    Income/(loss)
     from continuing
     operations  (13,292)     (23,770)     (52,071)       12,225      17,863

    Income from discontinued
     operations,
     net of tax  (17,114)          353           --           --          --

    Net income   (30,405)     (23,417)     (52,071)       12,225      17,863

    Net income per share:
     Basic         (0.31)       (0.16)       (0.28)         0.05        0.07
     Diluted       (0.31)       (0.28)       (0.28)         0.05        0.07
    Weighted average number
     of common shares
     outstanding:
      Basic    83,082,819  118,766,218  185,153,065  234,044,732 241,977,657
      Diluted  83,082,819  118,766,218  185,153,065  242,806,065 249,505,550


Pro Forma Combined Income Statement

    Quarterly data 1999   3 months      3 months     3 months      9 months
                            ending        ending       ending            to
                          31 March       30 June 30 September  30 September
                       '000 pounds   '000 pounds  '000 pounds   '000 pounds

    Revenues:
     Product sales          53,733        57,960       63,523       175,216
     Licensing and
      development            3,949           832        1,253         6,034
     Royalties                 387           716          339         1,442
     Other revenue             279           331          447         1,057

    Total sales and
     revenue                58,348        59,839       65,562       183,749

    Operating costs and expenses:
     Cost of sales          14,394        11,969       16,366        42,729
     Research and
      development           10,026         9,568       12,319        31,913
     Selling, general and
      administrative        21,201        22,334       21,624        65,159

    Total operating costs
     and expenses           45,621        43,871       50,309       139,801

    EBITDA                  12,727        15,968       15,253        43,948

    Depreciation and
     amortization          (3,841)       (3,906)      (4,321)      (12,068)

    Operating income         8,886        12,062       10,932        31,880

    Other income/(expense)
     Interest income           989         1,247        1,090         3,326
     Interest expense      (1,566)       (1,454)      (1,486)       (4,506)
     Foreign currency        (163)         (183)           23         (323)
     Other, net                556         (143)        (160)           253

    Total other income/
     (expense)               (184)         (533)        (533)       (1,250)

    Income before taxes      8,702        11,529       10,399        30,630

    Income taxes           (2,428)       (5,682)      (4,657)      (12,767)

    Net income               6,274         5,847        5,742        17,863

    Net income per share:
     Basic                    0.03          0.02         0.02          0.07
     Diluted                  0.03          0.02         0.02          0.07

    Weighted average number of common shares outstanding:
     Basic             240,438,985   242,149,929  243,312,483   241,977,657
     Diluted           247,390,800   248,264,519  251,446,294   249,505,550


    Pro Forma Combined Income Statement

    Quarterly data 1998
                 3 months     3 months     3 months     3 months        Year
                   ending       ending       ending       ending    Ended 31
                 31 March      30 June 30 September  31 December    December
              '000 pounds  '000 pounds  '000 pounds  '000 pounds '000 pounds

    Revenues:
     Product
      sales        36,830       44,414       40,893       53,406     175,543
     Licensing and
      development   1,401        2,351          453        2,878       7,083
     Royalties        438          859          343          583       2,223
     Other revenue    157          342          227          285       1,011

    Total sales and
     revenue       38,826       47,966       41,916       57,152     185,860

    Operating costs and expenses:
     Cost of
      sales        11,335       13,176       13,668       18,952      57,131
     Research and
      development   8,909        9,715        6,826       10,200      35,650
    Selling, general
     and adminis
     -trative      16,407       17,617       14,480       15,401      63,905

    Total operating
     costs and
     expenses      36,651       40,508       34,794       44,553     156,686

    EBITDA          2,175        7,458        6,942       12,599      29,174

    Depreciation and
     amorti
     -zation      (3,187)      (4,030)      (3,932)      (4,132)    (15,281)

    Operating
     income        (1012)        3,428        3,010        8,467      13,893

    Other income/(expense)
     Interest
      income          870        1,050          827        1,104       3,851
     Interest
      expense       (288)        (145)      (1,836)      (1,640)     (3,909)
     Foreign
      currency        115          267         (18)         (86)         278
     Other, net        30           65          435        (570)        (40)

    Total other income/
     (expense)        727        1,237        (592)      (1,192)         180

    Income before
     taxes          (285)        4,665        2,418        7,275      14,073

    Income taxes  (2,990)          308          534          300     (1,848)

    Net income    (3,275)        4,973        2,952        7,575      12,225

    Net income per share:
     Basic         (0.01)         0.02         0.01         0.03        0.05
     Diluted       (0.01)         0.02         0.01         0.03        0.05

    Weighted average number of common shares outstanding:
     Basic    221,453,169  236,799,603  238,478,589  239,259,296 234,044,732
     Diluted  230,612,442  245,869,067  246,095,575  248,223,566 242,806,410

    Reconciliation of Net Income under US GAAP
    (Merger Accounting) with UK GAAP (Purchase Accounting)


                                9 months to         Year to       Year to
                               30 September     31 December   31 December
                                       1999            1998          1997
                                '000 pounds     '000 pounds   '000 pounds

    Net income in accordance
     with US GAAP                    17,863          12,225      (52,071)

    Adjustments to conform to UK GAAP
     Purchase accounting adjustments:
      -Elimination of Roberts net
        income                     (12,228)        (10,026)       (1,535)
      In process Research and
        Development                      --              --        50,626
     Amortization of goodwill         5,103           6,709         2,459
     Recognition of deferred
      tax asset                     (1,771)         (7,765)       (1,312)
     Share option compensation
       costs                          6,380           3,313         1,412
     Tax benefit of share option
       deductions                     2,017           1,811            --

    Net income in accordance with
     UK GAAP                         17,364           6,267         (421)


    NET PRODUCT SALES DATA

                       Q1         Q2         Q3        Q4    Total
                     1999        1999      1999      1999     1999      % of
                     '000        '000      '000     '000      '000     Total
                   pounds      pounds    pounds   pounds    pounds

    ADDERALL       18,962     18,159     22,348             59,469        34%
    PENTASA         9,017      5,328     12,520             26,865        15%
    AGRYLIN         3,107     11,953      2,489             17,549        10%
    PROAMATINE      3,521      1,122      5,197              9,834         6%
    CALCIUMS        2,421      2,627      2,611              7,659         4%
    CARBATROL       1,563      2,374      2,635              6,572         4%
    DEXTROSTAT      1,168      1,588      1,335              4,091         2%

    OTC             3,705      3,003      4,963             11,671         7%

    OTHERS         10,269     11,809      9,422             31,500        18%
                   53,733     57,963     63,520       0    175,216       100%



    NET PRODUCT SALES DATA

                          Q1         Q2      Q3       Q4     Total
                        1998       1998    1998     1998      1998     % of
                        '000       '000    '000     '000      '000    Total
                      pounds     pounds  pounds   pounds    pounds

    ADDERALL           9,908     11,656   9,190   13,815    44,569      25%
    PENTASA                0      8,090   4,493    7,451    20,034      11%
    AGRYLIN            2,166      3,052   6,594    2,471    14,283       8%
    PROAMATINE         1,823      1,508   2,926    3,024     9,281       5%
    CALCIUMS           1,907      2,137   2,220    2,535     8,799       5%
    DEXTROSTAT           893        928     816      979     3,616       2%
    CARBATROL          1,625        621     297      679     3,222       2%

    OTC                3,809      4,614   2,909    4,296    15,628       9%

    OTHERS            14,699     11,808  11,448   18,156    56,111      32%

                      36,830     44,414  40,893   53,405   175,543     100%

    Currencies and exchange rates
    The following table details the exchange rates for one pound sterling
    expressed in US dollars use translation of the financial statements

                  Quarter      Quarter      Quarter      Quarter        Year
                 31 March      30 June      30 Sept       31 Dec      31 Dec
    1999

    Average        1,6337       1,6058       1,6129           --          --
    Closing                                  1,6438

    1998

    Average        1,6472       1,6614       1,6647       1,6709      1,6610
    Closing                                                           1,6638

    1997
                                                                      1,6397
    Average

    1996

    Average                                                           1,5733

    1995

    Average                                                           1,5803


SOURCE Shire Pharmaceuticals Group plc




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CONTACT:
Angus Russell, +44-1264-348545, Paul
McBarron, +44-1264-348527, both of Shire Pharmaceuticals Group
plc; David Yates, or Sophie Pender-Cudlip, both of Financial
Dynamics, +44-171-831-3113; or Julie Huang of Edelman Financial
Worldwide, 212-704-8114, for Shire Pharmaceuticals Group plc