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  Shire Pharmaceuticals Group: 2003 Restated Results

    BASINGSTOKE, England, August 3 /PRNewswire-FirstCall/ -- Shire
Pharmaceuticals Group plc (LSE: SHP) (NASDAQ: SHPGY) (TSX: SHQ) today
releases historical financial results for 2003.
    As indicated during the 2004 second quarter results presentation, the
results for all quarterly periods previously presented during 2003 have been
restated to reflect the expected disposal of our Biologics (vaccines)
business, which was accounted for as a discontinued operation in the 2004
second quarter results announcement.
    This statement is being published to provide the investment community
with a complete historic quarterly analysis of the 2003 unaudited statement
of operations that reflect these presentational changes.
    Notes to editors
    Shire Pharmaceuticals Group plc
    Shire Pharmaceuticals Group plc (Shire) is a global pharmaceutical
company with a strategic focus on meeting the needs of the specialist
physician and currently focuses on developing projects and marketing products
in the areas of central nervous system (CNS), gastrointestinal (GI), and
renal diseases. Shire has operations in the world's key pharmaceutical
markets (US, Canada, UK, France, Italy, Spain and Germany) as well as a
specialist drug delivery unit in the US.
    For further information on Shire, please visit the Company's website:
http://www.shire.com
    THE "SAFE HARBOR" STATEMENT UNDER THE PRIVATE SECURITIES LITIGATION
REFORM ACT OF 1995
    Statements included herein that are not historical facts are
forward-looking statements. Such forward-looking statements involve a number
of risks and uncertainties and are subject to change at any time. In the
event such risks or uncertainties materialize, Shire's results could be
materially affected. The risks and uncertainties include, but are not limited
to, risks associated with the inherent uncertainty of pharmaceutical
research, product development, manufacturing and commercialization, the
impact of competitive products, including, but not limited to, the impact on
Shire's Attention Deficit & Hyperactivity Disorder (ADHD) franchise, patents,
including but not limited to, legal challenges relating to Shire's ADHD
franchise, government regulation and approval, including but not limited to
the expected product approval dates of lanthanum carbonate (FOSRENOL(R)),
methylphenidate (METHYPATCH(R)), anagrelide hydrochloride (XAGRID(R)),
carbamazepine (BIPOTROL(R)) and the adult indication for extended release
mixed amphetamine salts (ADDERALL XR(R)), the implementation of the planned
reorganization and other risks and uncertainties detailed from time to time
in Shire's filings with the Securities and Exchange Commission.

    Results for 2003 by
    Quarter

    Unaudited
                                Q1 2003  Q2 2003  Q3 2003  Q4 2003   YR 2003

                                   $000     $000     $000     $000      $000
    Revenues:
    Product sales               254,561  245,671  232,282  271,793 1,004,307
    Licensing and development       394      702    1,355    1,226     3,677
    Royalties                    47,763   51,836   49,735   54,239   203,573
    Other revenues                    7        -        6        -        13

    Total revenues              302,725  298,209  283,378  327,258 1,211,570
    Costs and expenses:
    Cost of product sales        36,442   37,018   32,700   37,000   143,160
    Research and development     49,943   44,830   47,277   52,852   194,902
    Selling, general and        109,678  101,746   79,909   80,481   371,814
    administrative

    Total operating expenses    196,063  183,594  159,886  170,333   709,876

    Earnings before interest,
    tax, depreciation and
    amortisation
    Depreciation and             10,512   11,966   25,919   33,710    82,107
    amortisation

    Operating income             96,150  102,649   97,573  123,215   419,587
    Interest income               5,110    4,301    3,688    3,757    16,856
    Interest expense            (2,648)  (2,679)  (1,984)  (2,140)   (9,451)
    Other income/(expense),     (4,854)  (4,919)    (788) (10,084)  (20,645)
    net

    Total other                 (2,392)  (3,297)      916  (8,467)  (13,240)
    income/(expense), net

    Income from continuing
    operations before income
    taxes and equity in
    earnings of equity method
    investees                    93,758   99,352   98,489  114,748   406,347
    Income taxes               (24,526) (25,457) (25,139) (32,231) (107,353)
    Equity in earnings of         (449)  (1,205)     (45)      642   (1,057)
    equity method investees

    Income from continuing       68,783   72,690   73,305   83,159   297,937
    operations
    Income from discontinued    (5,717)  (7,205)  (8,686)    (278)  (21,886)
    operations
    Net income                   63,066   65,485   64,619   82,881   276,051




    Results for 2003 by Quarter

    Unaudited
                       Q1 2003    Q2 2003     Q3 2003     Q4 2003     YR 2003
                         $000        $000        $000        $000        $000
    EPS
    information
    Net income for     63,066      65,485      64,619      82,881     276,051
    basic EPS
    Add back:
    Interest            1,381       1,342       1,200       1,295       5,218
    charged on
    convertible
    debt

    Net income for     64,447      66,827      65,819      84,176     281,269
    diluted EPS

    EPS (per
    ordinary
    share)
    US GAAP
    Net income -        12.6c       13.1c       13.1c       16.7c       55.4c
    basic
    Net income -        12.3c       12.8c       12.8c       16.3c       54.2c
    diluted
    *Non US GAAP
    Net income -        13.4c       14.2c       14.4c       16.4c       58.4c
    diluted

    EPS (per ADS)
    US GAAP
    Net income -        37.7c       39.2c       39.2c       50.2c      166.2c
    basic
    Net income -        37.0c       38.4c       38.3c       48.9c      162.6c
    diluted
    *Non US GAAP
    Net income -        40.2c       42.6c       43.3c       49.1c      175.2c
    diluted

    Weighted
    average no.
    shares
    Ordinary -    501,989,884 501,504,962 494,827,334 495,031,261 498,212,826
    basic
    Ordinary -    522,547,153 522,559,387 515,826,822 516,404,663 518,967,395
    diluted
    Weighted
    average no. of
    shares
    ADS - basic   167,329,961 167,168,321 164,942,445 165,010,420 166,070,942
    ADS -
    diluted       174,182,384 174,186,462 171,942,274 172,134,888 172,989,131


    * This is a non-US GAAP financial measure. Management believes that the
presentation of this non-US GAAP financial measure provides useful
information to investors regarding Shire's underlying performance as the
costs associated with the reorganization, the gain on the sale of an
investment and the expected loss from discontinued operations are not part of
the Company's ongoing operations.

    Ratio analysis
    % Product Sales:
    Gross profit                   86%     85%     86%     86%     86%
    S, G & A                       43%     41%     34%     30%     37%
    % Total Revenues:
    R&D                            16%     15%     17%     16%     16%
    Operating income               32%     34%     34%     38%     35%
    Income from continuing         23%     24%     26%     25%     25%
    operations
    Net income                     21%     22%     23%     25%     23%




  SOURCE Shire Pharmaceuticals Group Plc




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